Results 171 to 180 of about 487,159 (190)
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Carcinogen-Induced, Free Radical-Mediated Reduction in Microsomal Membrane Fluidity: Reversal by Indole-3-propionic Acid

Journal of Bioenergetics and Biomembranes, 2001
Chromium (Cr) is a well established carcinogen, with Cr(III) accounting for much of the intracellular oxidative damage that this transition metal induces. Indole-3-propionic acid (IPA), a melatonin-related molecule, is a reported antioxidant and free radical scavenger. Concentration (1, 10, 100, 500, or 1000 microM) and time (15, 30, 45, 60, or 90 min)-
M, Karbownik   +3 more
openaire   +2 more sources

Effect of Bacteria-Derived Indole-3-Propionic Acid (IPA) in murine primary Hepatocytes

2017
Die Leber des Menschen ist ein Organ mit erstaunlichen Selbstheilungskräften. Die Frage nach Faktoren, die Gesundheit und Regenerationspotential dieses Organs erhalten, stehen seit längerem im Zentrum des wissenschaftlichen Interesses. Anatomisch einzigartig erhält die Leber den Großteil ihrer Blutversorgung aus dem Darm.
openaire   +2 more sources

One size might fit all: Indole-3-propionic acid potentiates pan-cancer immunotherapy

Cell Host & Microbe
Microbial-based therapies have the potential to combat immunotherapy resistance, extending the boundaries of oncological therapeutics. In a recent issue of Cell, Jia et al. demonstrates an example of microbial collaboration to produce a postbiotic that promotes the stemness program of CD8+ T cells to augment immunotherapy at the pan-cancer level.
Zheshun, Pi, Weici, Liu, Wenjun, Mao
openaire   +2 more sources

Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism

Science China Life Sciences
The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown.
Ziyi, Han   +3 more
openaire   +2 more sources

Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2021
Piotr Konopelski   +2 more
exaly  

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