Results 101 to 110 of about 329,198 (291)

Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024)

Molecules
Indole derivatives have become an important class of compounds in medicinal chemistry, recognized for their wide-ranging biological activities and therapeutic potential.
Xingyou Mo, Devendra Pratap Rao, Kirandeep Kaur, Roket Hassan, Ahmed S. Abdel-Samea, Sara Mahmoud Farhan, Stefan Bräse, Hamada Hashem   +7 more
doaj   +1 more source

Knife edge skimming for improved separation of molecular species by the deflector

, 2018
A knife edge for shaping a molecular beam is described to improve the spatial separation of the species in a molecular beam by the electrostatic deflector.
Bieker, Helen, Długołęcki, Karol, Gumprecht, Lars, Johny, Melby, Kierspel, Thomas, Küpper, Jochen, Mullins, Terry, Onvlee, Jolijn, Trippel, Sebastian, Ye, Hong   +9 more
core   +2 more sources

Application of recombinant DNA technology to studies on plant secondary metabolism [PDF]

, 2001
This review which is concerned with the application of recombinant DNA technology to studies on plant secondary metabolism, presents the more common plant transformation strategies and shows how these genetic approaches are being used in attempts to ...
Yeoman, Michael M., Zárate, Rafael
core   +1 more source

Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice

Advanced Science, EarlyView.
A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi, Shuang He, Chengyi Li, Hung Chan, Zhenfeng Liu, Bin Yang, Qing Li   +6 more
wiley   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, EarlyView.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +2 more sources

Molecular Analysis of Indole and Skatole Decomposition Metabolism in Acinetobacter piscicola p38 Utilizing Biochemical and Omics Approaches

Microorganisms
Indole and skatole (3-methylindole, C9H9N) are common nitrogen-containing heterocyclic pollutants found in waste, wastewater treatment plants, and public restrooms and are the most notorious compounds in animal feces.
Zhonghao Wang, Jiajin Sun, Pu Yang, Wanjun Zhang, Yihong Jiang, Qiang Liu, Yunqi Yang, Ruirong Hao, Gang Guo, Wenjie Huo, Qiang Zhang, Qinghong Li   +11 more
doaj   +1 more source

Genome-Wide Identification, Functional Analysis and Expression Profiling of the Aux/IAA Gene Family in Tomato [PDF]

, 2012
Auxin is a central hormone that exerts pleiotropic effects on plant growth including the development of roots, shoots, flowers and fruit. The perception and signaling of the plant hormone auxin rely on the cooperative action of several components,among
Abel, Abel, Abel, Bargmann, Carole Bassa, Chaabouni, Chaabouni, Corinne Audran-Delalande, Deng, Dharmasiri, Dharmasiri, Dreher, Eshed, Farid Regad, Finn, Hagen, Hamilton, Isabelle Mila, Jain, Jones, Kagale, Kalluri, Kepinski, Kloosterman, Leclercq, Li, Liscum, Mohamed Zouine, Mondher Bouzayen, Montgomery, Nebenführ, Oeller, Ohme-Takagi, Ottenschläger, Overvoorde, Paponov, Pirrello, Reed, Remington, Saitou, Sato, Szemenyei, Tamura, Tan, Theologis, Tiwari, Tiwari, Uehara, Ulmasov, Ulmasov, Wang, Wang, Wang, Wang, Yamamoto, Zuckerkandl   +55 more
core   +4 more sources

Engineering Active Metal and Nonmetal Sites in Porous Structures of Metal‐Hydroxide Clusters for Enhanced D2/H2 Uptake and Separation

Advanced Science, EarlyView.
Two supramolecular assembly frameworks, constructed from metal‐hydroxide clusters, are synthesized via coordination‐driven self‐assembly mediated by Co2+ and Cu2+ metal centers. One of them demonstrates exceptional D2 and H2 uptake capabilities, achieving the second‐highest uptake capacity for D2.
Zhuozhou Xie, Zhu Zhuo, Zi‐Ang Nan, Qing Li, Wenlin Wu, Yunzhe Zhou, Zi‐Xiu Lu, Jin Liu, Luyao Liu, Wenjing Wang, Daqiang Yuan, You‐Gui Huang   +11 more
wiley   +1 more source

Host‐Guest Doping Enables Room Temperature Phosphorescence from Triarylboranes

Angewandte Chemie, EarlyView.
While pure triarylboranes show RTP in annealed PMMA films, they do not in crystalline form, contrary to our previous report. However, crystalline host‐guest triarylborane systems show persistent afterglow up to 8 s even at 1 ppb guest loading. Computations identify triplet‐triplet energy transfer as the mechanism governing this efficient RTP.
Zhu Wu, Katrina Bergmann, Todd B. Marder, Bin Liu, Zachary M. Hudson   +4 more
wiley   +2 more sources

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source