Results 181 to 190 of about 178,765 (288)

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis. [PDF]

Int J Mol Med
Bai J, Wang R, Fan J, Su S, Si G, You Q, Sun A, Hu D, Gao S, Lv Y, Zhou F.   +10 more
europepmc   +1 more source

Exploration of structure–activity relationship of 2,4‐diaminopyrimidine derivatives as hematopoietic progenitor kinase 1 inhibitors

Bulletin of the Korean Chemical Society, EarlyView.
Targeting HPK1 is a promising strategy to restore T‐cell anti‐tumor immunity. We report the design and synthesis of novel 2,4‐diaminopyrimidine derivatives, focusing on systematic structure–activity relationship (SAR) analysis These findings identify key structural features for potent HPK1 inhibition, facilitating the discovery of next‐generation ...
Heechan Shin, Mi‐Ran Byun, Joon Seok Choi, Sujin Lee   +3 more
wiley   +1 more source

Gravid <i>Anopheles stephensi</i> Detects Indole for Oviposition Despite the Ablation of Antennae and Maxillary Palps. [PDF]

Insects
Agbetsi J, Xu J.
europepmc   +1 more source

Noise‐Blocking Interfacial Lamination of Small‐Molecule Acceptors for Enhanced Signal Clarity in Organic Photodetectors

Carbon Energy, EarlyView.
The structural design strategy employing the Y6‐BO interfacial lamination suppresses dark current by limiting solvent‐induced interfacial damage through the formation of uniformly arranged interfaces while optimizing charge transport to achieve superior detectivity.
Jihyun Lim, Hyunguk Park, Woongsik Jang, Jae Hyun Jeong, Dong Hwan Wang   +4 more
wiley   +1 more source

Microbiome-Derived Short-Chain Fatty Acids and Tryptophan Metabolites in Children with Autism Spectrum Disorder: A Stool-Urine Multi-Omics Analysis. [PDF]

Int J Mol Sci
Osredkar J, Fabjan T, Godnov U, Jekovec-Vrhovšek M, Osredkar D, Finderle P, Kumer K, Zorec M, Fanedl L, Avguštin G.   +9 more
europepmc   +1 more source

Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks

Chemistry – A European Journal, EarlyView.
A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan, Ethan J. French, Emerenziana Runco, Chetan B. Dhakan, Jinwu Yan, Hiroshi Nakashima, Michael T. McMahon, Assaf A. Gilad, Christian T. Farrar   +8 more
wiley   +1 more source

Indolyl substituted 4-oxobut-2-enoic acids. Synthesis and aza-Michael additions

Open Chemistry, 2007
Berkeš Dušan, Koren̆ová Anna, Šafár̆ Peter, Horváthová Helena, Prónayová Nadežda   +4 more
doaj   +1 more source

Cross-kingdom microbiome interactions along the gut-lung axis: immune-microecological coordination, shared mechanisms, and disease-context dependence in respiratory disorders. [PDF]

Gut Microbes
Yu J, Meng J, Shi Z, Zou J, Lai Z.
europepmc   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Gut microbiota-derived indole-3-propionic acid alleviates endoplasmic reticulum stress by regulating FMO2 in MASLD. [PDF]

Hepatol Commun
Luo Y, Zhang Y, Zhang Q, Li X, Cai K, Xu Y, Zhao R, Zhang S, Bai X, Chen H, Li H, Hong Y, Liao Q, Xie Z.   +13 more
europepmc   +1 more source