Results 191 to 200 of about 178,765 (288)

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

<i>O</i>-Heterocycles-Fused Indoles via Tandem 1,2-Indole Migration-Hydroxycyclization Reactions in 2-Hydroxyalkyl-3-propargylindoles. [PDF]

Org Lett
Renedo L, Solas M, Silva López C, Suárez-Pantiga S, Sanz R.   +4 more
europepmc   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Synthesis and structure-activity relationships of indole-3-butyric acid-based hydrazones: predicting their antibacterial and antioxidant potential through integrated experimental, molecular docking and DFT studies. [PDF]

RSC Adv
Azam M, Mashhood T, Bano S, Ibrahim M, Nadeem S, Zulfiqar H, Al-Shaalan NH, Alharthi S, Amin MA, Khan MU.   +9 more
europepmc   +1 more source

Cationic Sulfonium‐Based Tripodal Ligand and Its Rh(I) Complexes

Chemistry – A European Journal, EarlyView.
We report a cationic EP3‐type tripodal ligand based on an aromatic sulfonium cation (E = S+) along with a series of its Rh(I) complexes. Structural, spectroscopic, electrochemical, and computational analyses of these complexes compared to isostructural analogs (E = Si− or P) reveal pronounced electron density depletion at Rh in the sulfonium congener ...
Nitsan Barel, Shrouq Mujahed, Kamal Uddin Ansari, Katarzyna Młodzikowska‐Pieńko, Renana Gershoni‐Poranne, Yuri Tulchinsky   +5 more
wiley   +1 more source

Differential Analysis of IAA Anabolism Pathway Based on Bacillus cereus, Bacillus subtilis and Bacillus safensis Genome. [PDF]

Environ Microbiol Rep
Hou D, Zhai X, Zhang K, Cui J.
europepmc   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

Cell Signaling by Tryptophan Catabolism. [PDF]

Biochemistry
Torrelli-Diljohn A, Kulkarni B, Vitturi DA.   +2 more
europepmc   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Atroposelective construction of indole-fused diazocines <i>via</i> gold(i)-catalysed 8-<i>endo</i>-dig cyclisation. [PDF]

Chem Sci
Meraviglia S, Romanelli A, Iannelli P, Rizzato S, Contini A, Abbiati G, Pirovano V.   +6 more
europepmc   +1 more source