Results 211 to 220 of about 288,739 (291)

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Multifaceted modulation of human opioid receptors by kratom alkaloids: binding affinity, functional selectivity, and allosteric activity. [PDF]

Front Pharmacol
Hemby SE, Rangel-Grimaldo M, McIntosh S, Zheng J, Flores-Bocanegra L, Graf TN, Coover RA, Oberlies NH.   +7 more
europepmc   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Photochemical Aging of Indole SOA: Implications for Volatility and Optical Properties. [PDF]

Environ Sci Technol
Ajith TC, Calderon-Arrieta D, Pang H, Fang Z, Wang J, Knull J, Hajian N, Hill K, Li C, Laskin A, Rudich Y.   +10 more
europepmc   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Molecular mechanisms and therapeutic potential of tryptophan metabolism in gut-brain signaling transduction: a narrative review. [PDF]

J Neuroinflammation
Zhang J, Zhou Y, Mei X, Yan S, Mao J, Li Y, Bian Z, Li L, Ji, Lu T, Chen J, Su L.   +11 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Accelerated Combinatorial Drug Design for Human Immunodeficiency Virus Resistance through Seeded Multisite λ-Dynamics. [PDF]

J Chem Theory Comput
Bowling PE, Vilseck JZ, Brooks CL.
europepmc   +1 more source

Synthesis of trifunctional indole-imine-based Ag NPs as a molecular probe for selective colorimetric detection of Cd(ii), photo-catalytic and antimicrobial agent. [PDF]

RSC Adv
Kashif M, Raza AR, Akhtar S, Fawy KF, Sher M, Nishan U, Irfan MI, Abbas A.   +7 more
europepmc   +1 more source

Indole Loss: Hypertensive Link Between Dysbiosis and Diastolic Heart Failure. [PDF]

Circ Res
Horner KB, Mutchler AL.
europepmc   +1 more source