Results 271 to 280 of about 329,198 (291)

Reductive rearrangement of substituted quinolines to 2,3-disubstituted indoles enabled by water activation. [PDF]

Chem Sci
Spreckelmeyer N, Kim J, Lammert J, Horst ES, Zhang J, Studer A.   +5 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, EarlyView.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Nanoplasmonic SERS reveals previously uncharacterised indole derivative in E. coli metabolism

Vali M, Wyatt EW, Abbott K, Croft C, Lio P, Krauss TF, Khan M, Zarkan A, Baumberg JJ, Fusco D.   +9 more
europepmc   +1 more source

Palladium-Catalyzed One-Pot Synthesis of 3‑Arylindoles Based on <i>o</i>‑Iodoaniline with Aryl Hydrazones. [PDF]

ACS Omega
Du Z, Chen Y, Zhang T, Chen D, Liu Y.
europepmc   +1 more source

Direct Synthesis of Fused Indoles by Gold-Catalyzed Intramolecular Alkyne Cycloisomerization Cascade

, 2012
Kimio Hirano
openalex   +1 more source

Characterisation of bacteria‐induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease

The Journal of Pathology, EarlyView.
Abstract Enteropathogenic bacteria are a major cause of morbidity and mortality globally. While mouse models have been indispensable in advancing our understanding of infectious enteric diseases, key differences in intestinal microbiota and immunobiology between mice and humans underscore the need for alternative mammalian models that better ...
Daniel W. Hart, Aik Seng Ng, Patrycja Gazińska, Robert Goldin, Purva Gopal, Nicolize O'Dell, Ahmad Zargar, Lior Pytowski, Shamir Montazid, Chiara Bardella, James E. East, Ian P. Tomlinson, Nadine Koch, Nigel C. Bennett, Shazia Irshad   +14 more
wiley   +1 more source

Tryptophan Metabolism in Neurodevelopment and Its Implications For Neurodevelopmental Disorders. [PDF]

Mol Neurobiol
Giuliano MG, Tognini P.
europepmc   +1 more source