Results 211 to 220 of about 149,836 (290)

Targeted Profiling of Tryptophan- and Tyrosine-Derived Metabolites in Traditionally Fermented Foods. [PDF]

Plant Foods Hum Nutr
Ede-Çi̇ntesun E, Yaman M.
europepmc   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Chemical-mediated alteration of antibiotic susceptibility: mechanisms and potential new targets for antibiotic adjuvant discovery. [PDF]

J Bacteriol
Adams JME, El-Halfawy OM.
europepmc   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Accelerated Combinatorial Drug Design for Human Immunodeficiency Virus Resistance through Seeded Multisite λ-Dynamics. [PDF]

J Chem Theory Comput
Bowling PE, Vilseck JZ, Brooks CL.
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Functional Training Mitigates Reduced Circulating Indole-3-Lactate Levels in Persons With Relapsing-Remitting Multiple Sclerosis. [PDF]

Acta Physiol (Oxf)
Wences Chirino T, Adammek F, Belen S, Winker M, Proschinger S, Rademacher A, Schlagheck ML, Schenk A, Kupjetz M, Walzik D, Warnke C, Reuter M, Rosenberger F, Meyer T, McCann A, Ueland PM, Joisten N, Zimmer P.   +17 more
europepmc   +1 more source

Indoxyl Sulfate in the Gut-Kidney Axis: Pathophysiology and Clinical Significance in CKD-Associated Colorectal Cancer. [PDF]

Toxins (Basel)
Shimizu H, Niwa T.
europepmc   +1 more source

Inhibitory Oxidation Products of Indole-3-acetic Acid

Journal of Biological Chemistry, 1965
Cecil C. Still, T.T. Fukuyama, H.S. Moyed   +2 more
openaire   +1 more source

The role of gut microbes in production of aromatic carboxaldehydes. [PDF]

Gut Microbes
Kumar M, Son R, Preston SM, Glowacki RWP, Carr KM, Kim J, Ma JZ, Ahern PP, Claesen J, Sangwan N, Rieder F, Nemet I.   +11 more
europepmc   +1 more source