Results 21 to 30 of about 173,121 (147)

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase [PDF]

, 2019
Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities.
Winters, Maria, Wai, Jenny, Lewis-Ballester, Ariel, Pendergast, George C., DuHadaway, James B., Muller, Alexander J., Badir, Shorouk, Sheikh, Eesha, Malachowski, William Paul, Pham, Khoa N., Yeh, Syun-Ru   +10 more
core   +1 more source

Review of 10 years of research on breast cancer patients: Focus on indoleamine 2,3-dioxygenase

, 2021
Therapeutic manipulation of the immune system in cancer has been an extensive area of research in the field of oncoimmunology. Immunosuppression regulates antitumour immune responses.
Farooq, Asim, Zulfiqar, Bilal, Loya, Asif, Asghar, Kashif   +3 more
core   +1 more source

Impact of sidedness of colorectal cancer on tumor immunity.

PLoS ONE, 2020
BackgroundClinical and molecular characteristics differ between right-sided and left-sided colorectal cancer (CRC). This study aimed to clarify the correlation between CRC sidedness and tumor immunity.MethodsA total of 102 patients who underwent curative
Chie Takasu, Masaaki Nishi, Kozo Yoshikawa, Takuya Tokunaga, Hideya Kashihara, Toshiaki Yoshimoto, Mitsuo Shimada   +6 more
doaj   +1 more source

Neonatal Pig Sertoli Cells Survive Xenotransplantation by Creating an Immune Modulatory Environment Involving CD4 and CD8 Regulatory T Cells

Cell Transplantation, 2020
The acute cell-mediated immune response presents a significant barrier to xenotransplantation. Immune-privileged Sertoli cells (SC) can prolong the survival of co-transplanted cells including xenogeneic islets, hepatocytes, and neurons by protecting them
Gurvinder Kaur, Kandis Wright, Payal Mital, Taylor Hibler, Jonathan M. Miranda, Lea Ann Thompson, Katelyn Halley, Jannette M. Dufour   +7 more
doaj   +1 more source

Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
This study reveals that MarE, a heme‐dependent aromatic oxygenase, favors dioxygenation of β‐methyl‐l‐tryptophan in the absence of ascorbate and demonstrates how structural and redox tuning shifts its reactivity toward selective monooxygenation, yielding a 2‐oxindole scaffold. These findings offer new insights into enzyme‐controlled indole oxidation in
Romie C. Nguyen, Inchul Shin, Aimin Liu
wiley   +2 more sources

Dual metabolism-disrupted nanoparticles for reprogramming the immune microenvironment to potentiate cuproptosis immunotherapy

Materials Today Bio
Reprogramming the metabolism-mediated tumor microenvironment is a promising strategy to revitalize antitumor immunity. However, single metabolic modulation is often insufficient to achieve significant antitumor effects due to the intricate metabolic ...
Songyan Li, Zilin Ma, Yilei Zhao, Jie Yan, Xuechun Wang, Wen Zhao, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +8 more
doaj   +1 more source

Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta. [PDF]

, 1991
Previously, we pointed out the importance of the kynurenine metabolism in fetuses and neonates. We examined localization and developmental change of indoleamine 2,3-dioxygenase activity in human placenta.
Eguchi, Katsuto, Yonezawa, Masaru, Kamimura, Shigehito, Sekiba, Kaoru   +3 more
core   +1 more source

Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis

Stem Cell Research & Therapy, 2017
Background Due to their “natural immune privilege” and immunoregulatory properties human fibroblast-like limbal stem cells (f-LSCs) have acquired great interest as a potential tool for achieving immunotolerance.
Antonina Coppola, Laura Tomasello, Maria Pitrone, Salvatore Cillino, Pierina Richiusa, Giuseppe Pizzolanti, Carla Giordano   +6 more
doaj   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Lactobacillus Johnsonii YH1136 alleviates schizophrenia-like behavior in mice: a gut–microbiota–brain axis hypothesis study

BMC Microbiology
Based on the microbiota–gut–brain axis (MGBA) hypothesis, probiotics play an increasingly important role in treating various psychiatric disorders. Schizophrenia (SCZ) is a common mental disease with a complex pathogenesis and is challenging to treat ...
Liqin Zheng, Jinge Xin, Huiqian Ye, Ning Sun, Baoxing Gan, Xuemei Gong, Shusheng Bao, Min Xiang, Hesong Wang, Xueqin Ni, Hao Li, Tao Zhang   +11 more
doaj   +1 more source