Results 41 to 50 of about 173,121 (147)

Substrate Oxidation by Indoleamine 2,3-Dioxygenase : EVIDENCE FOR A COMMON REACTION MECHANISM

, 2015
The kynurenine pathway is the major route of l-tryptophan (l-Trp) catabolism in biology, leading ultimately to the formation of NAD(+). The initial and rate-limiting step of the kynurenine pathway involves oxidation of l-Trp to N-formylkynurenine.
M. Lee (6332354), J. Basran (7584656), S. Handa (7659650), Emma L. Raven (1270266), E. S. Booth (7659647)   +4 more
core   +6 more sources

Tissue Engineering and Regenerative Medicine: Perspectives and Challenges

MedComm, Volume 6, Issue 5, May 2025.
Tissue engineering and regenerative medicine. This review presents cell therapy, extracellular vesicle therapy, and tissue engineering in regenerative medicine, highlighting their key historical milestones, clinical applications, and current challenges.
Van T. Hoang, Quyen Thi Nguyen, Trang Thi Kieu Phan, Trang H. Pham, Nhung Thi Hong Dinh, Le Phuong Hoang Anh, Lan Thi Mai Dao, Van Dat Bui, Hong‐Nhung Dao, Duc Son Le, Anh Thi Lan Ngo, Quang‐Duong Le, Liem Nguyen Thanh   +12 more
wiley   +1 more source

Optimized psilocybin production in tryptophan catabolism‐repressed fungi

Microbial Biotechnology, Volume 17, Issue 11, November 2024.
Here, we developed an in vivo psilocybin production chassis, based on repression of l‐tryptophan catabolism. By genome mining, we identified two aminotransferase ARO8/9 orthologs in Aspergillus nidulans involved in l‐tryptophan catabolism. Double deletion of the aminotransferase genes aroH1 and aroH2 resulted in a 10‐fold increased psilocybin ...
Slavica Janevska, Sophie Weiser, Ying Huang, Jun Lin, Sandra Hoefgen, Katarina Jojić, Amelia E. Barber, Tim Schäfer, Janis Fricke, Dirk Hoffmeister, Lars Regestein, Vito Valiante, Johann E. Kufs   +12 more
wiley   +1 more source

Immune‐dysregulation harnessing in myeloid neoplasms

Cancer Medicine, Volume 13, Issue 17, September 2024.
Abstract Myeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation occur simultaneously in bone marrow microenvironments.
Mohammad Jafar Sharifi, Ling Xu, Nahid Nasiri, Mehnoosh Ashja‐Arvan, Hadis Soleimanzadeh, Mazdak Ganjalikhani‐Hakemi   +5 more
wiley   +1 more source

Nanomedicine and cancer immunotherapy: Focus on indoleamine 2,3-dioxygenase inhibitors

, 2017
Nanomedicine application in cancer immunotherapy is currently one of the most challenging areas in cancer therapeutic intervention. Innovative solutions have been provided by nanotechnology to deliver cytotoxic agents to the cancer cells partially ...
Farooq, RK, Mahroo, A, Zulfiqar, B, Jalal, N, Rashid, MU, Nasir, K, Asghar, K   +6 more
core   +1 more source

Binding of L-kynurenine to X. campestris tryptophan 2,3-dioxygenase

, 2021
The kynurenine pathway is the major route of tryptophan metabolism. The first step of this pathway is catalysed by one of two heme-dependent dioxygenase enzymes – tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) – leading initially ...
H Kwon (7106996), EL Raven (11681302), MH Jesani (11681293), J Clayden (11681296), CG Mowat (11681299), SJ Thackray (11681290), ES Booth (11681284), J Basran (7670954), LP Campbell (11681287), PCE Moody (7706810)   +9 more
core   +4 more sources

Xanthurenic acid: A role in brain intercellular signaling

Journal of Neurochemistry, Volume 168, Issue 9, Page 2303-2315, September 2024.
The two compounds are structural analogues and the level of XA is regulated by the activity of KMO producing the precursor 3‐hydroxykynurenine. XA accumulates in neurons, while KYNA is present in astrocytes. Unknown factors regulate the release of each of these compounds.
Michel Maitre, Omar Taleb, Hélène Jeltsch‐David, Christian Klein, Ayikoe‐Guy Mensah‐Nyagan   +4 more
wiley   +1 more source

The role of tryptophan metabolism and tolerogenic dendritic cells in maintaining immune tolerance: Insights into celiac disease pathogenesis

Immunity, Inflammation and Disease, Volume 12, Issue 8, August 2024.
Tryptophan, one of the eight essential amino acids, has evolved as a primary regulatory node in controlling immune responses. Celiac disease (CeD) is a developed immunological condition caused by gluten intolerance. Tolerogenic dendritic cells emerge as pivotal conductors, inducing immune tolerance and facilitating T‐reg differentiation to safeguard ...
Fatemeh Asgari, Mahdi Khodadoust, Abdolrahim Nikzamir, Somayeh Jahani‐Sherafat, Mostafa Rezaei Tavirani, Mohammad Rostami‐Nejad   +5 more
wiley   +1 more source

Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia.

, 2003
OBJECTIVE: Tryptophan degradation and depletion resulting from activation of indoleamine 2,3-dioxygenase is characteristic of inflammatory reactions and may control their intensity. Normal third-trimester pregnancy is characterized by a maternal systemic
Sargent, IL, Sargent, Ian, Redman, CW, Boyd, CA, Redman, Christopher, Kudo, Y   +5 more
core   +1 more source

Periodontal granulation tissue – To remove or not to remove, that is the question

Journal of Periodontal Research, Volume 59, Issue 4, Page 636-646, August 2024.
Abstract Formation of granulation tissue is a fundamental phase in periodontal wound healing with subsequent maturation leading to regeneration or repair. However, persistently inflamed granulation tissue presents in osseous defects as a result of periodontitis and is routinely disrupted and discarded with non‐surgical and surgical therapy to ...
Ye Han Sam, Luigi Nibali, Mandeep Ghuman
wiley   +1 more source