Results 1 to 10 of about 172,741 (147)

Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy. [PDF]

PLoS ONE, 2019
IntroductionDogs with protein-losing enteropathy (PLE) have decreased serum tryptophan concentrations, which may contribute to disease pathogenesis.
Aarti Kathrani, Victor Lezcano, Edward J Hall, Albert E Jergens, Yeon-Jung Seo, Jonathan P Mochel, Todd Atherly, Karin Allenspach   +7 more
doaj   +7 more sources

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science
Human adipose‐derived stem cells (hADSCs) possess immunomodulatory and multipotent properties, making them attractive candidates for regenerative therapies.
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
doaj   +2 more sources

The role of the immunoescape in colorectal cancer liver metastasis.

PLoS ONE, 2021
The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This
Chie Takasu, Shoko Yamashita, Yuji Morine, Kozo Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto, Mitsuo Shimada   +8 more
doaj   +2 more sources

Developing C2-Aroyl Indoles as Novel Inhibitors of IDO1 and Understanding Their Mechanism of Inhibition via Mass Spectroscopy, QM/MM Calculations and Molecular Dynamics Simulation

Frontiers in Chemistry, 2021
Indoleamine-2,3-dioxygenase (IDO1) and tryptophan dioxygenases are two heme based metalloenzymes that catalyze the tryptophan oxidation reaction by inserting molecular dioxygen to cleave the pyrrole ring.
Jyoti Chauhan, Srinivas R. Maddi, Kshatresh Dutta Dubey, Subhabrata Sen   +3 more
doaj   +1 more source

Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction

Frontiers in Immunology, 2022
ObjectiveThe occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification of patients with poor prognosis is essential for early intervention.
Xiaolin Zhang, Xiaolin Zhang, Yi Cai, Xu Su, Quanmin Jing, Haiwei Liu, Kun Na, Miaohan Qiu, Xiaoxiang Tian, Dan Liu, Tianxiao Wu, Chenghui Yan, Yaling Han, Yaling Han   +13 more
doaj   +1 more source

Role of IDO expression in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy

BMC Cancer, 2022
Background The role of the immune system in locally advanced rectal cancer (LARC) following preoperative chemoradiotherapy (CRT) has been widely investigated in recent years.
Chie Takasu, Masaaki Nishi, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto, Shohei Okikawa, Shoko Yamashita, Mitsuo Shimada   +10 more
doaj   +1 more source

Secretomes derived from osteogenically differentiated jaw periosteal cells inhibit phenotypic and functional maturation of CD14+ monocyte-derived dendritic cells

Frontiers in Immunology, 2023
The jaw periosteal tissue is generally recognized as a suitable source for the isolation of mesenchymal stem cells (MSCs). In previous studies we showed evidence that two- and three-dimensionally cultured jaw periosteum-derived MSCs (JPCs) are able to ...
Wanjing Cen, Felix Umrath, Felix Umrath, António José Salgado, António José Salgado, Siegmar Reinert, Dorothea Alexander   +6 more
doaj   +1 more source

Characterization of the blastogenic response to LPS of bovine peripheral blood mononuclear cells. [PDF]

PLoS ONE, 2018
Mitogens are diverse compounds of plant and microbial origin, widely employed to test immunocompetence in animals. The blastogenic response of bovine Peripheral Blood Mononuclear Cells (PBMC) to lypopolysaccharides (LPS) has been investigated in our ...
Massimo Amadori, Joel Fernando Soares-Filipe, Federica Riva, Andrea Vitali, Jessica Ruggeri, Nicola Lacetera   +5 more
doaj   +1 more source

SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses. [PDF]

PLoS ONE, 2012
Pattern recognition receptors and receptors for pro-inflammatory cytokines provide critical signals to drive the development of protective immunity to infection. Therefore, counter-regulatory pathways are required to ensure that overwhelming inflammation
Cortez McBerry, Rosa Maria Salazar Gonzalez, Nathaniel Shryock, Alexandra Dias, Julio Aliberti   +4 more
doaj   +1 more source

Hemophagocytic Lymphohistiocytosis Secondary to PD-1 and IDO Inhibition in a Patient with Refractory Glioblastoma

Case Reports in Oncology, 2020
Immune checkpoint inhibition (ICI)-based approaches have transformed the treatment landscape of numerous solid tumors. Glioblastoma (GBM) is an aggressive and almost universally fatal disease which is in need of novel treatment options, and combinations ...
Rohit Thummalapalli, Thatcher Heumann, Julie Stein, Sarah Khan, David S. Priemer, Amy S. Duffield, John Laterra, Rima Couzi, Michael Lim, Matthias Holdhoff   +9 more
doaj   +1 more source