Results 71 to 80 of about 173,121 (147)

Oxidation of L-tryptophan in biology:A comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase

, 2009
The family of haem dioxygenases catalyse the initial oxidative cleavage of L-tryptophan to N-formylkynurenine, which is the first, rate-limiting, step in the l-kynurenine pathway. In the present paper, we discuss and compare structure and function across
Efimov, Igor, Basran, Jaswir, Chauhan, Nishma, Rafice, Sara A., Raven, Emma Lloyd   +4 more
core   +1 more source

Indoleamine-pyrrole 2,3 dioxygenase (IDO1; INDO; IDO) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Indoleamine-pyrrole 2,3-dioxygenase (INDO); histone deacetylase (HDAC) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta.

Previously, we pointed out the importance of the kynurenine metabolism in fetuses and neonates. We examined localization and developmental change of indoleamine 2,3-dioxygenase activity in human placenta.
Eguchi, Katsuto, Yonezawa, Masaru, Kamimura, Shigehito, Sekiba, Kaoru   +3 more
core  

Ligand Migration in Human Indoleamine-2,3 Dioxygenase

, 2012
Human indoleamine 2,3-dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L-tryptophan (L-Trp) and other indoleamine derivatives.
Nienhaus, K., Nickel, E., Yeh, S.-R., Lu, C., Nienhaus, G. U.   +4 more
core  

Tryptophan metabolism in liver transplantation immune tolerance. [PDF]

Front Immunol
Li W, Ren A.
europepmc   +1 more source

Phytochemical Modulation of the Kynurenine Pathway (KYNP) and Its Emerging Mechanistic Insights into Cancer Progression: A Systematic Review. [PDF]

Int J Mol Sci
Tsantila EM, Christodoulou MC, Esslinger N, Neophytou CM.   +3 more
europepmc   +1 more source

Phase 1 study of KHK2455, a long-acting, potent and selective IDO1 inhibitor, in combination with avelumab in patients with locally advanced or metastatic urothelial carcinoma. [PDF]

J Immunother Cancer
Zakharia Y, de Spéville BD, Morales-Barrera R, Moreno I, Kilari D, Peguero J, Rao S, Shiue LH, Kanda H, Liu Y, Arora P, Vuppugalla R, Rodriguez-Vida A.   +12 more
europepmc   +1 more source

Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression. [PDF]

Int J Urol
Lemes DE, Santos AÁS, de Oliveira JL, Roman-Ramos H, Moreno ACR, Camacho CP, Pontes-Junior J, Dellê H.   +7 more
europepmc   +1 more source

Docking Analysis of Drugs Used in the Treatment of Alzheimer's Disease, Using Cell Membrane Receptors and Enzymes of the Kynurenine Pathway: A Pilot Study. [PDF]

Int J Mol Sci
Badawy AAB, Dawood S, Clanchy FIL, Williams RO, Stone TW.   +4 more
europepmc   +1 more source