Results 11 to 20 of about 3,209 (136)

Enzymatic reactions towards aldehydes: An overview [PDF]

Flavour and Fragrance Journal, Volume 38, Issue 4, Page 221-242, July 2023., 2023
Many aldehydes are volatile compounds with distinct and characteristic olfactory properties. The aldehydic functional group is reactive and, as such, an invaluable chemical multi-tool to make all sorts of products.
Dobiasova H., Jurkas V., Parmeggiani F., Rudroff F., Schober L., Winkler M.   +5 more
core   +2 more sources

Deciphering Tryptophan Oxygenation: Key Modulators of 2-Oxindole Formation in MarE. [PDF]

Angew Chem Int Ed Engl
This study reveals that MarE, a heme‐dependent aromatic oxygenase, favors dioxygenation of β‐methyl‐l‐tryptophan in the absence of ascorbate and demonstrates how structural and redox tuning shifts its reactivity toward selective monooxygenation, yielding a 2‐oxindole scaffold. These findings offer new insights into enzyme‐controlled indole oxidation in
Nguyen RC, Shin I, Liu A.
europepmc   +3 more sources

Optimized psilocybin production in tryptophan catabolism-repressed fungi. [PDF]

Microb Biotechnol
Here, we developed an in vivo psilocybin production chassis, based on repression of l‐tryptophan catabolism. By genome mining, we identified two aminotransferase ARO8/9 orthologs in Aspergillus nidulans involved in l‐tryptophan catabolism. Double deletion of the aminotransferase genes aroH1 and aroH2 resulted in a 10‐fold increased psilocybin ...
Janevska S, Weiser S, Huang Y, Lin J, Hoefgen S, Jojić K, Barber AE, Schäfer T, Fricke J, Hoffmeister D, Regestein L, Valiante V, Kufs JE.   +12 more
europepmc   +2 more sources

Hemophagocytic Lymphohistiocytosis Secondary to PD-1 and IDO Inhibition in a Patient with Refractory Glioblastoma

Case Reports in Oncology, 2020
Immune checkpoint inhibition (ICI)-based approaches have transformed the treatment landscape of numerous solid tumors. Glioblastoma (GBM) is an aggressive and almost universally fatal disease which is in need of novel treatment options, and combinations ...
Rohit Thummalapalli, Thatcher Heumann, Julie Stein, Sarah Khan, David S. Priemer, Amy S. Duffield, John Laterra, Rima Couzi, Michael Lim, Matthias Holdhoff   +9 more
doaj   +1 more source

Cell‐based therapies for the treatment of rheumatoid arthritis

Immunity, Inflammation and Disease, Volume 11, Issue 11, November 2023., 2023
Stem cell therapy for systemic sclerosis was evaluated. The efficacy of mesenchymal and hematopoietic stem cells was evaluated. Issues, including conditioning regimen, limitations, and complications, were discussed Abstract Autoimmune diseases, including rheumatoid arthritis that is the most prevalent rheumatic autoimmune disorder, affect autologous ...
Maryam Zare Moghaddam, Mohammad Javad Mousavi, Somayeh Ghotloo   +2 more
wiley   +1 more source

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

MedComm, Volume 4, Issue 5, October 2023., 2023
In this review, we summarize the pathogenesis of TB infection, therapeutic targets, and corresponding modulators, including first‐line medications, current clinical trial drugs and molecules in preclinical assessment. Our review provides valuable insights for future antituberculosis drug development efforts.
Jiaxing Yang, Laiying Zhang, Wenliang Qiao, Youfu Luo   +3 more
wiley   +1 more source

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
core   +1 more source

Tumor microenvironment signaling and therapeutics in cancer progression

Cancer Communications, Volume 43, Issue 5, Page 525-561, May 2023., 2023
Abstract Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new phenotypes to promote tumor cell invasion.
Anshika Goenka, Fatima Khan, Bhupender Verma, Priyanka Sinha, Crismita C. Dmello, Manasi P. Jogalekar, Prakash Gangadaran, Byeong‐Cheol Ahn   +7 more
wiley   +1 more source

GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγovercomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape [PDF]

, 2021
Immune escape mechanisms employed by neuroblastoma (NB) cells include secretion of immunosuppressive factors disrupting effective antitumor immunity. The use of cellular therapy to treat solid tumors needs to be implemented.
Caforio M., Camera A., Caruana I., Cifaldi L., De Angelis B., De Vito R., Del Bufalo F., Fanciulli M., Folgiero V., Fruci D., Goffredo B. M., Locatelli F., Quintarelli C., Sorino C., Vitale A., Weber G.   +15 more
core   +1 more source

Mediating the death of dormant tumor cells

Molecular & Cellular Oncology, 2018
How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3 ...
Yuying Liu, Jiadi Lv, Bo Huang
doaj   +1 more source