Results 121 to 130 of about 29,794,370 (246)
Frontiers in MedicineUlcerative colitis (UC) is a chronic inflammatory bowel disorder distinguished by alternating phases of remission and exacerbation. Restoring immune balance through the modulation of M1 macrophage polarization represents a potentially valuable ...
Zijian Gao +7 more
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Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance
Journal of Translational Medicine, 2019 Botticelli et al. proposed the activity of indoleamine-2,3-dioxygenase 1 (IDO) as a potential mechanism and predictive marker for primary resistance against anti-PD-1 treatment in the context of non-small cell lung cancer. However, there are a few points
Peter Kim Moon +2 more
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Metabolic reprogramming of the immune response in periodontitis
Periodontology 2000, EarlyView.Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon +3 more
wiley +1 more source
, 2011 The induction of oral tolerance increases the proportion of indoleamine 2,3-dioxygenase (IDO)-expressing CD11cdendritic cells (DCs) in Peyer's patches of tolerized mice.
Young-Ok Jung (46883) +11 more
core +1 more source
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]
, 2009 U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.) +3 more
core +1 more source
Translating gut microbiome research into therapies for type 1 diabetes
Experimental Physiology, EarlyView.Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok +2 more
wiley +1 more source
, 2019 The known benzonaphthyridine alkaloid, albogrisin A (1), and six new compounds, including two pyrazinone stereoisomers, albogrisin B (2)/B′ (2′), together with four 4H-pyrroloquinolinones, two diastereoisomers, albogrisin C (3)/C′ (3′), and their methyl ...
Du Gao (748330) +7 more
core +1 more source
International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers.
PLoS ONE, 2015 Tumor immune escape mechanisms are being regarded as suitable targets for tumor therapy. Among these, tryptophan catabolism plays a central role in creating an immunosuppressive environment, leading to tolerance to potentially immunogenic tumor antigens.
Paolo Puccetti +13 more
doaj +1 more source