Results 181 to 190 of about 29,794,370 (246)

Estrogen deprivation induces hepatic inflammation, Indoleamine-2,3-dioxygenase 1, tryptophan catabolism, and plasma cholesterol. [PDF]

Sci Rep
Guha P, Rishi A, Chini A, Bhat N, Gondrala PK, Brady B, Baniasadi HR, Perrotti LI, Mandal SS.   +8 more
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, Volume 59, Issue 9, September 2026.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Dietary tryptophan augments cancer-associated venous thrombogenicity mitigated by indoleamine 2,3-dioxygenase 1 inhibition. [PDF]

Blood Adv
Lotfollahzadeh S, Jose A, Yang X, Bathla T, Lazowski A, Hoekstra I, Sethuraman K, Potluri S, Dulberger KN, La J, Fillmore NR, Piqueras MDC, Lee N, Cabral H, Ravid K, Chitalia VC.   +15 more
europepmc   +1 more source

Endothelial Indoleamine-2,3-Dioxygenase-1 is not Critically Involved in Regulating Antitumor Immunity in the Central Nervous System. [PDF]

Int J Tryptophan Res, 2023
Abu Hejleh AP, Huck K, Jähne K, Tan CL, Lanz TV, Epping L, Sonner JK, Meuth SG, Henneberg A, Opitz CA, Herold-Mende C, Sahm F, Platten M, Sahm K.   +13 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, Volume 293, Issue 18, Page 5627-5644, September 2026.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Indoleamine 2,3-dioxygenase 1 inhibition reverses cancer-associated fibroblast-mediated immunosuppression in high-grade serous ovarian cancer. [PDF]

FEBS Open Bio
Lee H, Ho JY, Hwang IS, Choi YJ.
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Hydroxyamidine Derivatives as Indoleamine 2,3-Dioxygenase 1 Inhibitors. [PDF]

ACS Med Chem Lett
Qiu X, Liu Y, Zhou X, Zhao C, Meng Q, Zhao W, Shan G.   +6 more
europepmc   +1 more source

Correction to: Enhanced tryptophan-kynurenine metabolism via indoleamine 2,3-dioxygenase 1 induction in dermatomyositis. [PDF]

Clin Rheumatol, 2022
Wu D, Chen M, Chen S, Zhang S, Chen Y, Zhao Q, Xue K, Xue F, Chen X, Zhou M, Li H, Zheng J, Le Y, Cao H.   +13 more
europepmc   +1 more source

The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus

, 2017
Débora Moitinho Abram,1 Luis Gustavo Romani Fernandes,1,2 Antônio Celso Saragossa Ramos Filho,2 Patrícia Ucelli Simioni2–4 1Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Cidade Universit ...
Ramos Filho ACS, Simioni PU, Abram DM, Fernandes LGR   +3 more
core  

Indoleamine 2,3-dioxygenase 1 in cancer immunotherapy: from small-molecule inhibition to PROTAC-mediated degradation. [PDF]

Front Pharmacol
Li X, Meng H, Wang H, Zhang Y, Yu W.
europepmc   +1 more source