Results 91 to 100 of about 172,313 (331)

Synthesis of indolo[1,2-c]quinazolines from 2-alkynylaniline derivatives through Pd-catalyzed indole formation/cyclization with N,N-dimethylformamide dimethyl acetal

open access: yesBeilstein Journal of Organic Chemistry, 2018
An efficient strategy for the synthesis of 6-unsubstituted indolo[1,2-c]quinazolines is described. The Pd-catalyzed reaction of o-(o-aminophenylethynyl) trifluoroacetanilides with Ar–B(OH)2 afforded 2-(o-aminophenyl)-3-arylindoles, that were converted to
Antonio Arcadi   +6 more
doaj   +1 more source

Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats

open access: yesFrontiers in Pharmacology, 2019
Datura metel L. has been frequently used in Chinese traditional medicine. However, little is known on the chemical composition and in vivo metabolism of its seeds.
Cong Xia   +9 more
doaj   +1 more source

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

open access: yesScientific Reports, 2015
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However,
T. Hubbard   +7 more
semanticscholar   +1 more source

Unveiling the Excited‐State Dynamics and Interfacial Interactions in Dye‐Sensitized NaNdF4 Nanoparticles for Efficient Photothermal Effect

open access: yesAdvanced Science, EarlyView.
A new class of efficient photothermal agents based on dye‐sensitized NaNdF4 is developed. The coordination and aggregation states of cypate dyes on lanthanide nanoparticles are identified, revealing the influence of interfacial interactions on resonant energy transfer and synergetic heat generation.
Jiacheng Gong   +12 more
wiley   +1 more source

Simultaneous Multi‐Resonant Thermally Activated Delayed Fluorescence and Room Temperature Phosphorescence from Biluminescent Nitrogen‐Containing Indolocarbazoles

open access: yesAdvanced Science, EarlyView.
An extremely rare type of organic biluminescent emission is reported that consists of delayed emission resulting from both the fluorescence (multi‐resonance thermally activated delayed fluorescence) and phosphorescence spectra at room temperature, and the lifetimes of the two processes exhibit opposing dependence with temperature.
Oliver S. Lee   +5 more
wiley   +1 more source

(1H-Benzo[d][1,2,3]triazol-1-yl)(5-bromo-1-hydroxy-1H-indol-3-yl)methanone

open access: yesMolbank, 2014
The title compound was easily prepared by a nitrosoarene-alkyne cycloaddition reaction carried out in toluene at 80 °C. The product is a highly functionalized compound that can be further derivatized through various functional group interconversion ...
Francesco Tibiletti   +5 more
doaj   +1 more source

Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe

open access: yesAdvanced Science, EarlyView.
This study presents a novel approach for intraoperative identification of the IDH1 genotype in glioma patients using a surface‐enhanced Raman scattering (SERS) probe to measure glutathione and hydrogen peroxide. By integrating AI‐driven deep learning algorithms, the method achieves rapid and accurate genotype differentiation, offering the potential to ...
Hang Yin   +14 more
wiley   +1 more source

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

open access: yesAdvanced Science, EarlyView.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn   +6 more
wiley   +1 more source

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

open access: yesAdvanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan   +12 more
wiley   +1 more source

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