Results 71 to 80 of about 45,952 (286)
Advanced Science, EarlyView.ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo +14 more
wiley +1 more source
Carbonylated Indoles from PdII-Catalyzed Intermolecular Reactions of Indolyl Cores
, 2019 International audienceThis review summarizes palladium-catalyzed carbonylation, transmetalation, and cross-coupling reactions that lead to carbonylated indoles from indoles and indolyl compounds.
Le Bras, Jean, Muzart, Jacques
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Advanced Science, EarlyView.Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He +10 more
wiley +1 more source
Advanced Science, EarlyView.Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
3-Alkylated indoles by reduction of sulfonyl indoles under flow chemical conditions [PDF]
, 2019 Reduction of 3-(1-arylsulfonylalkyl) indoles (sulfonyl indoles) using polymer-supported sodium borohydride under flow chemical conditions allows an efficient synthesis of 3-alkylindoles with a notable waste minimization and reduced solvent consumption.
Alessandro Palmieri +2 more
core +1 more source
Advanced Science, EarlyView.Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley +1 more source
, 1996 Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually.
Sundberg, Richard J.
core
Single‐Step Electrochemical Aptasensor for Melatonin Detection in Unprocessed Plasma
Advanced Science, EarlyView.Melatonin is a well‐known biomarker with significant potential for clinical use in diagnosing circadian rhythm sleep disorders (CRSDs) and monitoring patients with documented circadian clock disruption. An electrochemical aptamer‐based biosensor (E‐aptasensor), employing an optimized population of melatonin aptamers, has been proposed as a solution for
Hamed Shieh +6 more
wiley +1 more source
Indole Compounds. V*. 3-(2-Mercaptoethyl)indoles and bis-[ 3-(2-Thioethyl)indoles], Sulphur Analogs of Tryptophol, 5-Hydroxytryptophol, and Other Bz-Substituted Tryptophols [PDF]
, 1968 The one-step cyclization of 4-benzylthiobutanal diethyl acetal with various hydrazine hydrochlorides under mild conditions is described. The obtained 3-(2 -benzylthioethyl)indoles were debenzylated with sodium in liquid ammonia to the corresponding 3-
Goleš, D. +3 more
core +1 more source
Regioselective hydrodebromination of polybrominated indoles
, 2014 The mixture of sodium borohydride and N,N,N′,N′-tetramethylethylenediamine in combination with a palladium catalyst is a mild and efficient system for the regioselective hydrodebromination of polybrominated indoles with both N-donating and N-withdrawing ...
Giorgio Chelucci +5 more
core +1 more source