Results 91 to 100 of about 45,952 (286)

Gut Microbiota and Cardiovascular Uremic Toxicities

Toxins, 2018
Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in patients with chronic kidney disease (CKD). Numerous CVD risk factors in CKD patients have been described, but these do not fully explain the high pervasiveness of CVD ...
Manuel T. Velasquez, Patricia Centron, Ian Barrows, Rama Dwivedi, Dominic S. Raj   +4 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Catalytic Enantioselective Additions of Indoles to Nitroalkenes

, 2016
Catalytic Enantioselective Additions of Indoles to ...
Madhu Ganesh (2226970), Daniel Seidel (348104)   +1 more
core   +3 more sources

Dehydration triggered asymmetric hydrogenation of 3-(a-hydroxyalkyl)indoles.

, 2011
Dehydration triggered asymmetric hydrogenation of 3-(a-hydroxyalkyl ...
段英, 江国防, 唐杰, 余长斌, 王躲生, 陈木旺, 周永贵   +6 more
core  

Indole 3-acetate and response to therapy in borderline resectable or locally advanced pancreatic cancer

Frontiers in Oncology
Background/AimsIt was recently reported that a higher concentration of the bacterially produced metabolite indole 3-acetate (3-IAA) in blood was linked to a better response to chemotherapy in patients with metastatic pancreatic ductal adenocarcinoma ...
Peder R. Braadland, Peder R. Braadland, Ingvild Farnes, Ingvild Farnes, Elin H. Kure, Elin H. Kure, Sheraz Yaqub, Sheraz Yaqub, Adrian McCann, Per M. Ueland, Per M. Ueland, Knut Jørgen Labori, Knut Jørgen Labori, Johannes R. Hov, Johannes R. Hov, Johannes R. Hov   +15 more
doaj   +1 more source

Triarylmethyl Cation Catalysis: A Tunable Lewis Acid Organo­catalyst for the Synthesis of Bisindolylmethanes

SynOpen, 2017
Triarylmethyl cations serve as tunable organocatalysts for the synthesis of bisindolylmethanes. The catalyst structure can be modified to increase or decrease reactivity as needed to match the requirements of the substrate. High yields are achieved for a
Nicholas G. Boekell, Dana J. Cerone, Maria M. Boucher, Phong K. Quach, Wilfried B. Tentchou Nganyak, Christine G. Reavis, Ifeanyi I. Okoh, Jordan O. A. Reid, Hayley E. Berg, Briana A. Chang, Cheyenne S. Brindle   +10 more
doaj   +1 more source

Sc(OTf)₃-catalyzed alkylation of indoles with propargyl alcohols: an expeditious synthesis of 3-substituted indoles

, 2007
Indoles undergo smooth alkylation with propargylic alcohols in the presence of 10 mol % of scandium triflate under mild conditions to produce 3-propargylated indoles in excellent yields with high ...
Narayana Kumar, G. G. K. S., Yadav, J. S., Subba Reddy, B. V., Raghavendra Rao, K. V.   +3 more
core   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Palladium-catalyzed selective assembly of carbamoylated indoles and aminophenanthridinones via β-carbon elimination switch

Communications Chemistry
Palladium-catalyzed switchable β-carbon elimination to extrude norbornene for selective synthesis of different heterocyclic skeletons is a long-standing challenge.
Bo-Sheng Zhang, Yi-Ming Wang, Jun-Shi Zhou, Xin-Yue Fu, Sven Trienes, Tian-Jiao Guo, Xue-Ya Gou, Xi-Cun Wang, Zheng-Jun Quan, Lutz Ackermann, Yong-Min Liang   +10 more
doaj   +1 more source