Results 91 to 100 of about 41,236 (276)
Advanced Science, EarlyView.Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun +6 more
wiley +1 more source
Advanced Science, EarlyView.A new generation of high‐precision fluorescent probes based on the lysosomal characteristics in tumor metabolic reprogramming and overexpressed tumor markers. The probe (CN‐D‐GGT) selectively label cancer cells in co‐culture systems and distinguish tumor lesions from inflamedand normal tissues in vivo, enabling precise tumor imaging.
Yang Shen +6 more
wiley +1 more source
Novel synthesis of 3,4-fused indoles [PDF]
, 2001 The goal of this project was to synthesize 3,4-fused indoles having a variety of ring sizes and a variety of functional groups. This has been accomplished by the development of a novel palladium-catalyzed route to 3,4-fused indoles. The key steps are two
Hubbard, Jeremiah Wallace
core +1 more source
Molecules, 2018 Novel 1,4-naphthoquinones possessing indole scaffolds were prepared by the reaction of 2-hydroxy-1,4-naphthoquinone-substituted salicylic aldehydes and indoles using In(OTf)3 as a catalyst. The method has the advantages of simple operation, mild reaction
Xiaojuan Yang, Liqiang Wu
doaj +1 more source
Advanced Science, EarlyView.A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen +11 more
wiley +1 more source
Synthesis of pyrrolobenzothiadiazepines, pyrrolizidines and indoles [PDF]
In this thesis, novel syntheses of analogues of pyrrolobenzodiazepines (PBDs) are described. These compounds are of great interest as synthetic targets due to their potential medical properties.
Joãoa, Heidi
core
An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as Reductant [PDF]
, 2011 An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as ...
曹亮亮 +3 more
core
Solventless Clay-Promoted Friedel−Crafts Reaction of Indoles with α-Amido Sulfones: Unexpected Synthesis of 3-(1-Arylsulfonylalkyl) Indoles [PDF]
, 2016 Friedel−Crafts reaction of indoles with α-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl) indoles in good yield.
Elisabetta Torregiani (2530045) +3 more
core +3 more sources
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
Advanced Science, EarlyView.AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
Advanced Science, EarlyView.An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang +8 more
wiley +1 more source