Results 91 to 100 of about 44,366 (284)

Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross‐Disciplinary Innovation

open access: yesAdvanced Science, EarlyView.
Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

open access: yesAdvanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang   +7 more
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

open access: yesAdvanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori   +10 more
wiley   +1 more source

Electrophilic Substitutions of Indoles and Pyrroles: [PDF]

open access: yes, 2007
The kinetics of the electrophilic substitutions of indoles and pyrroles have been investigated and new sythetic applications (i.e. electrophilic allylations and benzylations of indoles and regio- and stereoselective ring opening reactions of epoxides ...
Westermaier, Martin
core   +1 more source

Synthesis of 3-(2-nitroalkyl) indoles by reaction of 3-(1-arylsulfonylalkyl) indoles with nitroalkanes

open access: yes, 2007
Sulfonyl indoles act as effective precursors of vinylogous imino derivatives in the reaction with nitroalkanes under basic conditions leading to the corresponding nitro indoles in good yield. This procedure represents an effective option to the classical
Alessandro Palmieri   +5 more
core   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

open access: yesAdvanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou   +10 more
wiley   +1 more source

Síndrome alucinógeno, indoles alucinógenos [PDF]

open access: yes, 2016
Hallucinogenic syndrome and hallucinogenic indoles This work summarizes the information about the hallucinogenic mushrooms: history, active components, toxicity, clinical studies, diagnosis, treatment and legal aspects.Síndrome alucinógeno, indoles ...
L. Serés García
core   +1 more source

Palladium-Catalyzed Cyclization/Carboalkoxylation of Alkenyl Indoles

open access: yes, 2016
Reaction of 1-methyl-2-(4-pentenyl)indole with a catalytic amount of PdCl2(CH3CN)2 (5 mol %) and a stoichiometric amount of CuCl2 (3 equiv) in methanol under CO (1 atm) at room temperature for 30 min led to cyclization/carboalkoxylation to form the ...
Ross A. Widenhoefer (1375383)   +1 more
core   +1 more source

SIZ1‐Mediated SUMOylation of LBD29 Recruits ARF7 to Fine‐Tune Auxin Signaling in Lateral Root Development

open access: yesAdvanced Science, EarlyView.
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui   +7 more
wiley   +1 more source

Palladium-catalyzed selective assembly of carbamoylated indoles and aminophenanthridinones via β-carbon elimination switch

open access: yesCommunications Chemistry
Palladium-catalyzed switchable β-carbon elimination to extrude norbornene for selective synthesis of different heterocyclic skeletons is a long-standing challenge.
Bo-Sheng Zhang   +10 more
doaj   +1 more source

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