Results 51 to 60 of about 44,366 (284)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
PLoS ONE, 2019 Imidazolium salts are shown to catalyze the rapid room temperature reaction of indoles or naphthol with aldehydes to provide bis(indolyl)methanes or bis(naphthol)methane in excellent yields and the reaction proceeds optimally in dichloromethane with no ...
Xu Wang, Courtney C Aldrich
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Frontiers in Pharmacology, 2022 Caper (Capparis spinosa L.) is a perennial shrub of the family Capparaceae, endemic to circum-Mediterranean countries. Caper carries a renowned nutritional value, especially in terms of vitamins and antioxidants related to the occurrence of flavonoids ...
Hassan Annaz +8 more
doaj +1 more source
, 1996 Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually.
Sundberg, Richard J.
core +1 more source
Síntese ambientalmente adequada de 3-selenil-indóis [PDF]
, 2014 (Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2014No presente trabalho desenvolveu-se uma nova metodologia sintética ambientalmente ...
Ferreira, Natasha Londero
core
Direct Oxidative C-P Bond Formation of Indoles with Dialkyl Phosphites
, 2012 The direct phosphonation of indoles was developed. In this reaction, dialkyl phosphites and indoles were used as substrates, and the C-P bond was formed through oxidative coupling mediated by silver(I) acetate.
Wu, Fan +4 more
core +1 more source
Acetoacetates Derived From Vegetable Oils: A Platform for Tailor‐Made Vinylogous Urethane Foams
Advanced Functional Materials, EarlyView.A renewable vegetable oil is converted into acetoacetate‐functionalized precursors for the preparation of catalyst‐free vinylogous urethane foams. Room‐temperature foaming with n‐pentane generates lightweight cellular materials, while the choice of amine enables control over foam structure and mechanical properties.
Krzysztof Polaczek +8 more
wiley +1 more source
Green Halogenation of Indoles with Oxone–Halide
, 2023 Oxidative functionalization of indoles is one of the most widely used approaches to exploit the synthetic utility of indoles. In continuation of our research interest in the green oxidation of indoles, we further explore the oxidation of indoles with ...
Shaojun Cheng (16699668) +11 more
core +2 more sources
Synthesis of Indole Derivatives via Aryl Triazole Ring-Opening and Subsequent Cyclization
MoleculesA metal-free two-step synthetic approach for obtaining indole derivatives from aryl triazole fragment-containing compounds has been developed. In the first step, the Dimroth equilibrium, followed by nitrogen extrusion, Wolff rearrangement, and amine ...
Aleksejs Burcevs +4 more
doaj +1 more source