Results 31 to 40 of about 41,075 (284)

The benefits of indolence [PDF]

Communications of the ACM, 2019
The Communications Web site, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of Communications , we'll publish selected posts or excerpts. twitter Follow us on Twitter at http://twitter ...
openaire   +1 more source

Chemoselective N-acylation of indoles using thioesters as acyl source

Beilstein Journal of Organic Chemistry, 2022
The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source. A
Tianri Du, Xiangmu Wei, Honghong Xu, Xin Zhang, Ruiru Fang, Zheng Yuan, Zhi Liang, Yahui Li   +7 more
doaj   +1 more source

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

Frontiers in Immunology, 2023
IntroductionStaphylococcus epidermidis is a commensal bacterium ubiquitously present on human skin. This species is considered as a key member of the healthy skin microbiota, involved in the defense against pathogens, modulating the immune system, and ...
Leslie Landemaine, Leslie Landemaine, Gregory Da Costa, Gregory Da Costa, Elsa Fissier, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Marie-Laure Michel, Romain Briandet, Harry Sokol, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Philippe Langella, Cecile Clavaud, Mathias L. Richard, Mathias L. Richard   +23 more
doaj   +1 more source

Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc [PDF]

, 2017
Marine molluscs are rich in biologically active natural products that provide new potential sources of anti-inflammatory agents. Here we used bioassay guided fractionation of extracts from the muricid Dicathais orbita to identify brominated indoles with ...
Rudd, David, Lei Liu, Seymour, Lisa M, Ahmad, Tarek B, Benkendorff, Kirsten, Kotiw, Michael, Michael Kotiw, Lisa Seymour, Peter Mouatt, Ahmad, Tarek B., Smith, Joshua, Liu, Lei, Mouatt, Peter, Kirsten Benkendorff, Benkendorff, Kirsten, Dr, Seymour, Lisa M., David Rudd, Tarek Ahmad, Joshua Smith   +18 more
core   +1 more source

A Novel C3/C4-Fused Indole Scaffold through Acid-Catalyzed Cascade Reaction

Molecules
3,4-bridged indoles are underrepresented among the vast number of indoles described in the literature. Attempts to access 3,4-macrocyclized indoles led to the unexpected formation of a novel tetracyclic indole through intramolecular acid-catalyzed ring ...
Felix Potlitz, Gottfried J. Palm, Anja Bodtke, Michael Lammers, Dennis Schade, Andreas Link   +5 more
doaj   +1 more source

A General and Scalable Synthesis of Polysubstituted Indoles

Molecules, 2020
A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported.
David Tejedor, Raquel Diana-Rivero, Fernando García-Tellado   +2 more
doaj   +1 more source

Oxidative rearrangement of indoles to oxindoles

, 2012
An unexpected oxidative rearrangement was observed when indoles substituted with 2-hydroxymalonates were subjected to typical iodination conditions.
Rodriguez, Arantxa, MacRory, Kerry L., Moran, Wesley J.   +2 more
core   +1 more source

Direct C3-functionalization of indoles with alpha-heteroaryl-substituted methyl alcohols via a metal-free hydrogen autotransfer-type reaction

, 2023
The transition metal-free Cs2CO3/oxone®-mediated C3-alkylation of indoles proceeds in moderate to high yields with a variety of C4–C7 functionalized indoles and is applicable to 2-, 3- and 4-hydroxymethyl pyridines and related electron-deficient ...
Ethan, Pazur, Nikhil, Tasker, Peter, Wipf   +2 more
core   +1 more source

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Frontiers in Chemistry, 2019
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi, Xiaolin Shi, Xiaolin Shi, Xiaowei Li, Xiaowei Li, Xiaowei Li, Xiangqian Li, Dayong Shi   +7 more
doaj   +1 more source

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

Molecules, 2020
The 1,3-benzothiazole (BTZ) ring may offer a valid option for scaffold-hopping from indole derivatives. Several BTZs have clinically relevant roles, mainly as CNS medicines and diagnostic agents, with riluzole being one of the most famous examples ...
Serge Mignani, Jean-Pierre Majoral, Jean-François Desaphy, Giovanni Lentini   +3 more
doaj   +1 more source