Results 31 to 40 of about 44,366 (284)

Synthesis and X-ray Crystal Structure Analysis of Substituted 1,2,4-Triazolo [4’,3’:2,3]pyridazino[4,5-b]indole and Its Precursor

Crystals, 2023
The hit compound 1,2,4-triazolo[4’,3’:2,3]pyridazino[4,5-b]indole 3 was synthesized from the reflux of 4-amino-5-indolyl-1,2,4-triazole-3-thione 1 with 4′-bromoacetophenone 2 in methanol catalyzed by concentrated HCl and the desired final molecule was ...
Ahmed T. A. Boraei, Elsayed H. Eltamany, Matti Haukka, Saied M. Soliman, Assem Barakat, Manar Sopaih   +5 more
doaj   +1 more source

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

Frontiers in Immunology, 2023
IntroductionStaphylococcus epidermidis is a commensal bacterium ubiquitously present on human skin. This species is considered as a key member of the healthy skin microbiota, involved in the defense against pathogens, modulating the immune system, and ...
Leslie Landemaine, Leslie Landemaine, Gregory Da Costa, Gregory Da Costa, Elsa Fissier, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Marie-Laure Michel, Romain Briandet, Harry Sokol, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Philippe Langella, Cecile Clavaud, Mathias L. Richard, Mathias L. Richard   +23 more
doaj   +1 more source

Marine Indole Alkaloids [PDF]

Marine Drugs, 2015
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in ...
Netz, Natalie, Opatz, Till
openaire   +4 more sources

A Novel C3/C4-Fused Indole Scaffold through Acid-Catalyzed Cascade Reaction

Molecules
3,4-bridged indoles are underrepresented among the vast number of indoles described in the literature. Attempts to access 3,4-macrocyclized indoles led to the unexpected formation of a novel tetracyclic indole through intramolecular acid-catalyzed ring ...
Felix Potlitz, Gottfried J. Palm, Anja Bodtke, Michael Lammers, Dennis Schade, Andreas Link   +5 more
doaj   +1 more source

Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc [PDF]

, 2017
Marine molluscs are rich in biologically active natural products that provide new potential sources of anti-inflammatory agents. Here we used bioassay guided fractionation of extracts from the muricid Dicathais orbita to identify brominated indoles with ...
Rudd, David, Lei Liu, Seymour, Lisa M, Ahmad, Tarek B, Benkendorff, Kirsten, Kotiw, Michael, Michael Kotiw, Lisa Seymour, Peter Mouatt, Ahmad, Tarek B., Smith, Joshua, Liu, Lei, Mouatt, Peter, Kirsten Benkendorff, Benkendorff, Kirsten, Dr, Seymour, Lisa M., David Rudd, Tarek Ahmad, Joshua Smith   +18 more
core   +1 more source

pi-Bond Directed C-2 Amination of Indoles: Catalysis Development, Mechanistic Investigation, and Substrate Scope [PDF]

, 2022
Cooperative functionalization of N-heterocycles, common motifs present in pharmaceuticals, agrochemicals, functional mate-rials, and natural products, is attractive but a challenging task.
Gregory, Cook, Dinesh, Kumar, Sandeep, Vemula   +2 more
core   +1 more source

A General and Scalable Synthesis of Polysubstituted Indoles

Molecules, 2020
A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported.
David Tejedor, Raquel Diana-Rivero, Fernando García-Tellado   +2 more
doaj   +1 more source

New Approaches to Indoles and Indole Alkaloids [PDF]

Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings, 2013
Second only to pyridines, indoles are among the most common aromatic scaffolds present in bioactive molecules. The 5-hydroxy indole moiety alone has currently >10,500 substructure hits Among the many indole-containing alkaloid scaffolds, ergot alkaloids comprise a notable group of natural products of great biological activities. The striking biological
Peter Wipf, Filip Petronijevic
openaire   +1 more source

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Frontiers in Chemistry, 2019
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi, Xiaolin Shi, Xiaolin Shi, Xiaowei Li, Xiaowei Li, Xiaowei Li, Xiangqian Li, Dayong Shi   +7 more
doaj   +1 more source

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

Molecules, 2020
The 1,3-benzothiazole (BTZ) ring may offer a valid option for scaffold-hopping from indole derivatives. Several BTZs have clinically relevant roles, mainly as CNS medicines and diagnostic agents, with riluzole being one of the most famous examples ...
Serge Mignani, Jean-Pierre Majoral, Jean-François Desaphy, Giovanni Lentini   +3 more
doaj   +1 more source