Results 11 to 20 of about 41,236 (276)
, 2018 Embedded medium-sized carbacycles and cyclohepta [b] indoles occur frequently as scaffold elements in natural products and bioactive compounds. Described herein is a conceptionally novel photochemically triggered cascade process to these scaffolds.
Navriti Chadha, Om Silakari
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Efficient copper-catalyzed synthesis of C3-alkylated indoles from indoles and alcohols [PDF]
, 2021 A highly efficient copper(II) catalyst system for alkylation of indoles with alcohols via hydrogen borrowing method has been developed to afford C3-alkylated indoles in good to excellent yields. Cu(OAc)2 in the combination with dppm ligand has been found
Van Phuc, Ban +6 more
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When Is an Indole Not an Indole? [PDF]
Clinical Chemistry, 1998 An indole is not an indole when it is a naphthalene derivative! We routinely measure 5-hydroxyindoleacetic acid (5HIAA) by a long-established method using nitrosonaphthol, as first described by Udenfriend in 1955 (1), but with various modifications to improve specificity (2).
Kathryn Brownbill, John A Martin
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Diastereoselective Access to Triazolo[1,2‑a]indolines via a Bio-Inspired Oxidative Cyclization of NH-Indoles [PDF]
, 2022 Establishing three-dimensional chemicals by using the C2–C3 π bond of indoles has always been a research hotspot in organic synthesis; however, employing the oxidative C2–C3 π bond of indoles to generate imine which would lead to the N1–C2 π bond ...
Kui Du (3488084) +6 more
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Programmable Deuteration of Indoles via Reverse Deuterium Exchange [PDF]
, 2023 Methods for selective deuterium incorporation into drug-like molecules have become extremely valuable due to the commercial, mechanistic, and biological importance of deuterated compounds.
Greener, Andrew +3 more
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Undirected, Pd-catalysed deuteration of indoles with programmable regioselectivity [PDF]
, 2022 Methods for selective deuterium-incorporation into drug-like molecules have become extremely valuable due to the commercial and biological importance of deuterated compounds.
Rachael, McNulty +3 more
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Umpolung of Indoles: Triflic Acid-Mediated C3-Regioselective Hydroarylation of N-H Indoles [PDF]
, 2022 The direct dearomative addition of arenes to the C3-position of unprotected indoles is reported under operationally simple condi-tions, using triflic acid at room temperature.
Vincent, Gandon +4 more
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BMC Plant Biology, 2023 Background Strobilanthes cusia (Nees) Kuntze is a traditional medical plant distributed widely in south China. The indole compounds that originated from the plant are responsible for its pharmacological activities.
Chang Liu +4 more
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Natural Indole Alkaloids from Marine Fungi: Chemical Diversity and Biological Activities
Pharmaceutical Fronts, 2021 The indole scaffold is one of the most important heterocyclic ring systems for pharmaceutical development, and serves as an active moiety in several clinical drugs.
Jiao Li, Chun-Lin Zhuang
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Molecules, 2020 The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles is developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted
Xue Yan +4 more
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