Results 41 to 50 of about 41,236 (276)

Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation

Frontiers in Immunology, 2023
IntroductionStaphylococcus epidermidis is a commensal bacterium ubiquitously present on human skin. This species is considered as a key member of the healthy skin microbiota, involved in the defense against pathogens, modulating the immune system, and ...
Leslie Landemaine, Leslie Landemaine, Gregory Da Costa, Gregory Da Costa, Elsa Fissier, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Marie-Laure Michel, Romain Briandet, Harry Sokol, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Philippe Langella, Cecile Clavaud, Mathias L. Richard, Mathias L. Richard   +23 more
doaj   +1 more source

Anti-inflammatory activity and structure-activity relationships of brominated indoles from a marine mollusc [PDF]

, 2017
Marine molluscs are rich in biologically active natural products that provide new potential sources of anti-inflammatory agents. Here we used bioassay guided fractionation of extracts from the muricid Dicathais orbita to identify brominated indoles with ...
Rudd, David, Lei Liu, Seymour, Lisa M, Ahmad, Tarek B, Benkendorff, Kirsten, Kotiw, Michael, Michael Kotiw, Lisa Seymour, Peter Mouatt, Ahmad, Tarek B., Smith, Joshua, Liu, Lei, Mouatt, Peter, Kirsten Benkendorff, Benkendorff, Kirsten, Dr, Seymour, Lisa M., David Rudd, Tarek Ahmad, Joshua Smith   +18 more
core   +1 more source

Pd-Catalyzed asymmetric hydrogenation of 3-(toluenesulfonamidoalkyl)indoles [PDF]

, 2012
A series of 2-substituted 3-(toluenesulfonamidoalkyl)indoles was synthesized by application of (EtO)(2)POH or iodine as the catalyst, and was hydrogenated using chiral Pd catalyst, giving the 2,3-disubstituted indolines with up to 97 ...
Duan, Ying, Chen, Mu-Wang, Zhou, Yong-Gui, Chen, Qing-An, Yu, Chang-Bin, 周永贵   +5 more
core   +1 more source

A Novel C3/C4-Fused Indole Scaffold through Acid-Catalyzed Cascade Reaction

Molecules
3,4-bridged indoles are underrepresented among the vast number of indoles described in the literature. Attempts to access 3,4-macrocyclized indoles led to the unexpected formation of a novel tetracyclic indole through intramolecular acid-catalyzed ring ...
Felix Potlitz, Gottfried J. Palm, Anja Bodtke, Michael Lammers, Dennis Schade, Andreas Link   +5 more
doaj   +1 more source

A General and Scalable Synthesis of Polysubstituted Indoles

Molecules, 2020
A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported.
David Tejedor, Raquel Diana-Rivero, Fernando García-Tellado   +2 more
doaj   +1 more source

Photocatalytic Alkylation of Pyrroles and Indoles with α-Diazo Esters [PDF]

, 2019
This article describes direct photoalkylation of electron-rich aromatic compounds with diazo compoiunds. C-2 alkylated indoles and pyrroles are obtained with good yields even though the photocatalyst (Ru(bpy)3Cl2) loading is as low as 0.075 mol %.
Jakub, Durka, Dorota, Gryko, Łukasz, Ciszewski   +2 more
core   +1 more source

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Frontiers in Chemistry, 2019
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi, Xiaolin Shi, Xiaolin Shi, Xiaowei Li, Xiaowei Li, Xiaowei Li, Xiangqian Li, Dayong Shi   +7 more
doaj   +1 more source

From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies

Molecules, 2020
The 1,3-benzothiazole (BTZ) ring may offer a valid option for scaffold-hopping from indole derivatives. Several BTZs have clinically relevant roles, mainly as CNS medicines and diagnostic agents, with riluzole being one of the most famous examples ...
Serge Mignani, Jean-Pierre Majoral, Jean-François Desaphy, Giovanni Lentini   +3 more
doaj   +1 more source

Base-Promoted S_NAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles

Molecules, 2019
KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has ...
Muhammad Asif Iqbal, Hina Mehmood, Jiaying Lv, Ruimao Hua   +3 more
doaj   +1 more source

Synthesis, Characterization, Fluorescence Properties, and DFT Modeling of Difluoroboron Biindolediketonates

Molecules, 2023
We report a simple and efficient strategy to enhance the fluorescence of biocompatible biindole diketonates (bdks) in the visible spectrum through difluoroboronation (BF2bdks complexes).
Angelo Maspero, Federico Vavassori, Luca Nardo, Guglielmo Vesco, Jenny G. Vitillo, Andrea Penoni   +5 more
doaj   +1 more source