Results 101 to 110 of about 104,731 (310)
Gramine derivatives targeting Ca2+ channels and Ser/Thr phosphatases: A new dual strategy for the treatment of neurodegenerative diseases [PDF]
, 2016 This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Journal of Medicinal Chemistry , copyright © American Chemical Society after peer review.
Alzheimer A. +11 more
core +3 more sources
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Brønsted Acid-Catalyzed Cascade Reactions Involving 1,2-Indole Migration [PDF]
, 2015 A cascade reaction of indoles with propargylic diols involving an unprecedented metal-free 1,2-indole migration onto an alkyne is here described. DFT calculations support a mechanism consisting in a concerted nucleophilic attack of the indole nucleus
Fernández Rodríguez, Manuel A. +4 more
core +1 more source
Advanced Science, EarlyView.An intermolecular aza‐Paternò‐Büchi reaction of indoles and acyclic imines is enabled by visible‐light‐driven triplet energy transfer, providing azetidine‐fused indolines up to 93% yield for 30 examples and providing a novel protocol to access previously inaccessible scaffolds. ABSTRACT Currently, successful examples of the aza‐[2+2] photocycloaddition
Gang Yang +3 more
wiley +1 more source
N‐heterocyclic carbene catalyzed photoenolization/Diels–Alder reaction of acid fluorides [PDF]
, 2019 The combination of light activation and N‐heterocyclic carbene (NHC) organocatalysis has enabled the use of acid fluorides as substrates in a UVA‐light‐mediated photochemical transformation previously observed only with aromatic aldehydes and ketones ...
Agrawal, Arush +6 more
core +1 more source
Advanced Science, EarlyView.An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao +11 more
wiley +1 more source
Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering [PDF]
, 2021 Yongliang Liu +8 more
openalex +1 more source
Advanced Science, EarlyView.In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li +8 more
wiley +1 more source
Advanced Science, EarlyView.Trace water transforms from an impurity to a design handle for ternary organic solar cells. During solvent evaporation, minimal amounts organize transient hydrogen‐bonding networks that steer component migration and set the morphology. The mechanism enables reproducible morphology locking and identifies a practical co‐solvent threshold near H2O:CF = 0 ...
Yue Ren +6 more
wiley +1 more source
A network of jasmonate‐responsive bHLH factors modulate monoterpenoid indole alkaloid biosynthesis in Catharanthus roseus [PDF]
, 2017 Barunava Patra +3 more
openalex +1 more source