Results 121 to 130 of about 41,075 (284)
Novel synthesis of 3,4-fused indoles
, 2001 The goal of this project was to synthesize 3,4-fused indoles having a variety of ring sizes and a variety of functional groups. This has been accomplished by the development of a novel palladium-catalyzed route to 3,4-fused indoles. The key steps are two
Hubbard, Jeremiah Wallace
core +1 more source
The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation
American Journal of Hematology, EarlyView.ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa +4 more
wiley +2 more sources
Synthesis of pyrrolobenzothiadiazepines, pyrrolizidines and indoles
In this thesis, novel syntheses of analogues of pyrrolobenzodiazepines (PBDs) are described. These compounds are of great interest as synthetic targets due to their potential medical properties.
Joãoa, Heidi
core
An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as Reductant
, 2011 An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as ...
曹亮亮 +3 more
core
Animal Models and Experimental Medicine, EarlyView.The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad +9 more
wiley +1 more source
Rapid Fragment Screening by 19F Steady‐State Free Precession NMR
Angewandte Chemie, EarlyView.19F$^{19}{\rm F}$ SSFP NMR is a broadband and very sensitive experiment for detecting protein–ligand interactions. The method enables rapid fragment screening at low micromolar protein concentrations, even for challenging drug targets such as intrinsically disordered proteins.
Laura Ruduša +8 more
wiley +2 more sources
, 2016 Friedel−Crafts reaction of indoles with α-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl) indoles in good yield.
Elisabetta Torregiani (2530045) +3 more
core +2 more sources
Angewandte Chemie, EarlyView.Heterogeneous iron‐catalyzed environmentally benign and sustainable CH‐oxidative esterification methodology has been developed for the synthesis of esters. This challenging reaction has been achieved by the rational design of specific single atom iron‐based catalyst with Fe‐N4 active centers, which empowered the oxidative esterification of methyl and ...
Zhuang Ma +8 more
wiley +2 more sources
2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy
Angewandte Chemie, EarlyView.A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng +8 more
wiley +2 more sources