Results 141 to 150 of about 41,236 (276)
Speciation‐Controlled C–F Bond Functionalization Enabled by Zwitterionic Pnictinidenes
Angewandte Chemie, EarlyView.Zwitterionic pnictinidenes turn C–F activation into C–X bond construction, enabling broad defluorinative functionalization of polyfluoro(hetero)arenes under mild conditions. Rather than following a metallomimetic Sb(I)/Sb(III) redox turnover, catalysis is redirected by ligand scrambling into a redox‐neutral manifold, revealing catalyst speciation as a ...
Irene Sánchez‐Sordo +4 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa +4 more
wiley +2 more sources
Novas metodologias eficientes para a reação de transferência de diazo: preparação de y-azido-a-diazo-b-ceto éster e aplicações na síntese de amidas e indóis [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015.Neste trabalho foram desenvolvidas novas metodologias para a obtenção de diazo compostos 1,3 ...
Dutra, Luiz Gustavo
core
Flavin Catalysts in Organic Synthesis
Angewandte Chemie, EarlyView.Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley +2 more sources
N‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides
Angewandte Chemie, EarlyView.N‐Alkoxysulfurdiimide reagents when combined with organometallic reagents lead directly to primary sulfonimidamide products. The reactions are broad in scope, encompassing aryl, heteroaryl, and alkyl carbon substituents. The reactivity of the N‐alkoxysulfurdiimide reagents can be correlated with the electron‐withdrawing ability of the N‐substituent ...
Suzanne E. Davison +6 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Bias‐aware machine learning identified an underexplored imidazolidinone catalyst with broad competitive performance in iminium‐based reactions. Experimental benchmarking shows how data‐driven prioritization can uncover overlooked catalyst scaffolds from sparse and historically biased literature data.
Jiajing Li +4 more
wiley +2 more sources
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Solventless clay-promoted Friedel-Crafts reaction of indoles with alpha-amido sulfones: Unexpected synthesis of 3-(1-arylsulfonylalkyl) indoles [PDF]
, 2006 Friedel-Crafts reaction of indoles with r-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl)indoles in good yield.
PETRINI, Marino +3 more
core
Angewandte Chemie, EarlyView.Enantioselective aminoarylation of ortho‐allyl anilines is achieved under mild conditions. Key to success is the electrostatically‐directed nature of the key aminopalladation step, achieved by using the sulfonated chiral ligand sSPhos on palladium. A detailed study of electronic trends allows tuning of the sulfonamide protecting group to enable good ...
Max Kadarauch +4 more
wiley +2 more sources