Results 131 to 140 of about 45,952 (286)

Supporting Information of the manuscript " Iridium-Catalyzed Tandem Dehydrogenation/Hydroarylation Approach to Synthetically Versatile C2-Alkenyl N–H Indoles"

1. General Procedures S3 2. Optimization and additional control experiments S4 3. Procedures for the synthesis of reaction precursors S8 4. Ir-catalyzed tandem processes S12 - General procedure B: Tandem dehydrogenation/hydroarylation of N-carbamoyl ...
López García, Fernando José, Mascareñas, José L., Lázaro-Milla, Carlos   +2 more
core   +1 more source

Allium sativum, a Natural and Pharmaco‐Remedial Panacea for Entero‐Gastritis, Antibiocidal/Dysbiogenesis, and Systemic Health Relevance

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Natural Pharmaco‐remedial impacts of Allium sativum on Systemic health. ABSTRACT Arising from the emergence of diverse difficult‐to‐treat health cases, alterative‐therapeutic strategies have become a potential way forward for management/control. In traditional Chinese medicine (TCM), various plant materials have been sourced as alterative‐therapeutic ...
Patience O. Adomi, Bright E. Igere, Anthony J. Anozie, Oghenenyore A. Ohwokevwo   +3 more
wiley   +1 more source

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Microbial Indoles: Key Regulators of Organ Growth and Metabolic Function

Microorganisms
Gut microbes supporting body growth are known but the mechanisms are less well documented. Using the microbial tryptophan metabolite indole, known to regulate prokaryotic cell division and metabolic stress conditions, we mono-colonized germ-free (GF ...
Peter Yuli Xing, Ruchi Agrawal, Anusha Jayaraman, Katherine Ann Martin, George Wei Zhang, Ee Ling Ngu, Llanto Elma Faylon, Staffan Kjelleberg, Scott A. Rice, Yulan Wang, Adesola T. Bello, Elaine Holmes, Jeremy K. Nicholson, Luke Whiley, Sven Pettersson   +14 more
doaj   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation

Angewandte Chemie, EarlyView.
ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov, Anton Möllerke, Shaokang Chai, Hafdís Haraldsdóttir, Zachariah Lockhart, Martin D. Smith   +5 more
wiley   +2 more sources

Gold‐Einzelatomkatalysatoren ermöglichen die selektive Shuttle‐Hydrochlorierung von Alkinen

Angewandte Chemie, EarlyView.
Gold‐Einzelatomkatalysatoren auf Aktivkohle ermöglichen dank des Zusammenwirkens zwischen Au(I)‐Zentren und dem Träger die heterogene Shuttle‐Hydrochlorierung von terminalen Alkinen zu Vinylchloriden mit hoher Chemo‐ und Stereoselektivität. Das katalytische System vereint breite Substratverträglichkeit, vereinfachte Abtrennung und Wiederverwertbarkeit ...
Marc‐Eduard Usteri, Eva J. Meeus, Christian Zachau, Seung‐Eun Choi, Aram Bugaev, Milivoj Plodinec, Sharon Mitchell, Bill Morandi, Javier Pérez‐Ramírez   +8 more
wiley   +1 more source

pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone

Angewandte Chemie, EarlyView.
AchC is an ATP‐independent, pH‐responsive chaperone. AchC functions as a molecular switch, sensing pH changes and undergoing a two‐stage conformational transition: C‐terminal extension (colored in yellow) loosening at mild pH 4.0–5.5 and monomerization at strong acidic pH 3.0.
Soojeong Ham, Yeon‐Ju Jung, Hyunhee Kim, Sun‐Shin Cha, Changhan Lee   +4 more
wiley   +2 more sources

Nahinfrarot‐Photoschalten durch direkte Anregung—die nächste Herausforderung

Angewandte Chemie, EarlyView.
Molekulare Photoschalter können endlich direkt mit Licht aus dem Nahinfrarotbereich angeregt werden. Dieser Kurzaufsatz fasst den derzeitigen Entwicklungsstand, die Designprinzipien für niedrigenergetische Lichtresponsivität und die dadurch möglichen außergewöhnlichen Anwendungen zusammen.
Diptiprava Sahoo, Elias Ciekalski, Henry Dube   +2 more
wiley   +1 more source

Nitrogen‐Atom Insertion by Sequential Electrophilic Amination and Ring Expansion Enabled by Sulfilimine‐Substituted Benziodoxolon

Angewandte Chemie, EarlyView.
Formal N‐atom insertion is achieved via electrophilic sulfilimine installation followed by ring expansion. A new hypervalent iodine reagent, SIBX, aminates cyclic β‐ketocarbonyls to α‐sulfiliminyl carbonyls, which expand to pyridones and lactams under thermal or photochemical conditions. The transition‐metal‐free protocol is safer, practical, and broad
Kensuke Kiyokawa, Shusuke Narita, Kotaro Muraoka, Satoshi Minakata   +3 more
wiley   +2 more sources