Results 151 to 160 of about 41,236 (276)

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +2 more sources

CH activation and CH2 double activation of indolines: towards the synthesis of aspidospermidine and aspidofractinine [PDF]

, 2009
This thesis is concerned with the total synthesis of the two Aspidosperma alkaloid natural products, aspidospermidine and aspidofractinine. The two targets have a common pentacyclic molecular framework unique to this class of indole alkaloids ...
Whiting, Sally
core  

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

Augmented indoles

ARKIVOC, 2006
David StC. Black, Michelle F. Channon, Kylie A. Clayton, Glenn C. Condie, Jason B. Harper, Naresh Kumar, Karin Pchalek, Tutik Dwi Wahyuningsih   +7 more
doaj   +1 more source

Stereodivergent C‐(Hetero)Aryl Glycosylation by Nickel‐Catalyzed Redox‐Neutral Cross‐Coupling of Glycosyl Sulfonyl Hydrazides

Angewandte Chemie, EarlyView.
A nickel‐catalyzed C–C cross‐coupling protocol employing bench‐stable glycosyl sulfonyl hydrazides as practical glycosyl radical precursors is reported. A variety of (hetero)aryl iodides underwent cross‐coupling under redox‐neutral conditions to afford structurally diverse unprotected C‐(hetero)aryl glycosides.
Cai‐Ming Wang, Wen Wei, Jun Wu, Ming Joo Koh   +3 more
wiley   +2 more sources

Durch anomere Amide ermöglichte divergente Synthese unsymmetrischer Harnstoffe, Carbamate, Thioester und Amide aus Aldehyden

Angewandte Chemie, EarlyView.
Eine divergente Aldehyd‐Funktionalisierungssequenz, ermöglicht durch ein anomeres Amid, erlaubt den Ein‐Topf‐Zugang zu unsymmetrischen Harnstoffen, Carbamaten, Thiocarbamaten, Thioestern und Amiden. Entscheidend für diese Transformation ist die Bildung von N‐Boc‐Hydroxamat‐Intermediaten, die als Plattformen für eine orthogonale Aktivierung über Lossen ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Synthesis of 2-(α-trifluoromethylamino)indoles <i>via</i> stepwise cascade transformation of imidoyl sulfoxonium ylides with <i>ortho</i>-chloromethyl anilines. [PDF]

RSC Adv
Pan Y, Wang Y, Zhou X, Liu T, Zhang X, Jiang T.   +5 more
europepmc   +1 more source

Application of metal-free conditions to a one-pot Leimgruber-Batcho indole synthesis. [PDF]

RSC Adv
Halsvik B, Haug BE.
europepmc   +1 more source

Palladium-catalyzed intramolecular dearomatization of indoles <i>via</i> Heck/Stille cross-coupling with organostannanes. [PDF]

RSC Adv
Qi Z, Hong J, Ji B, Chen C, Xiao Y, Song B, Lv Y, An Z, Ma P.   +8 more
europepmc   +1 more source

<i>O</i>-Heterocycles-Fused Indoles via Tandem 1,2-Indole Migration-Hydroxycyclization Reactions in 2-Hydroxyalkyl-3-propargylindoles. [PDF]

Org Lett
Renedo L, Solas M, Silva López C, Suárez-Pantiga S, Sanz R.   +4 more
europepmc   +1 more source