Results 171 to 180 of about 41,075 (284)

Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks

Chemistry – A European Journal, EarlyView.
A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan, Ethan J. French, Emerenziana Runco, Chetan B. Dhakan, Jinwu Yan, Hiroshi Nakashima, Michael T. McMahon, Assaf A. Gilad, Christian T. Farrar   +8 more
wiley   +1 more source

Recent developments in the organocatalytic asymmetric cycloaddition/annulation reactions involving indolylmethanols. [PDF]

RSC Adv
Patel A, Harshit, Iype E, Kumar I.
europepmc   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Correction: C-2 functionalization of indoles with xanthate-lactam derivatives by radical-oxidative coupling, an approach to <i>Aspidosperma</i> alkaloids. [PDF]

RSC Adv
Pastrana M, Mijangos MV, Miranda LD.
europepmc   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Regioselective C2-Sulfonylation of Indoles and Pyrroles via SO₂ Insertions. [PDF]

Org Lett
Bai R, Cheng WL, Peng CY, Chen YH, Wang PH, Lee CF.   +5 more
europepmc   +1 more source

Probing the Influence of Sulfur–Aromatic Interactions on the Electronic Structure of Gas‐Phase Peptides

Chemistry – A European Journal, EarlyView.
Just as fingerprints reveal identity, spectroscopic fingerprints reveal molecular secrets. In this article, we show parts of the unique fingerprint of the sulfur–aromatic interaction. By measuring how this force alters the electronic structure of gas‐phase peptides, we provide a fundamental understanding of interactions that give insights into the ...
Laura Pille, Carlos Ortiz‐Mahecha, Bart Oostenrijk, Juliette Leroux, Marion Girod, Konstantin Hirsch, Luke MacAleese, Robert Horst Meißner, Debora Scuderi, Isaak Unger, Vicente Zamudio‐Bayer, Sadia Bari, Lucas Schwob   +12 more
wiley   +1 more source

Molecular iodine catalyzed C3-quaternization <i>via</i> oxidative dearomatization of indoles: direct access to 3,3-di(indolyl)indolin-2-ones. [PDF]

RSC Adv
Singh N, Kokatla HP, Naddi N, Inapanuri M.   +3 more
europepmc   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

Chemistry – A European Journal, EarlyView.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +1 more source

2-Lithiomethylindoles: Untapped Anions for the Synthesis of 2-Functionalized Indoles. [PDF]

J Org Chem
Gómez-Gil S, Solas M, Suárez-Pantiga S, Sanz R.   +3 more
europepmc   +1 more source