Results 171 to 180 of about 172,313 (331)

Recent advances in catalytic approaches for the synthesis of 3-substituted indoles: mechanisms and strategies. [PDF]

open access: yesRSC Adv
Abdu Musad Saleh E   +9 more
europepmc   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Novel cross-feeding human gut microbes metabolizing tryptophan to indole-3-propionate. [PDF]

open access: yesGut Microbes
Zünd JN   +7 more
europepmc   +1 more source

Photosensitizer Repositioning Affords an Enantiocomplementary Enzyme for [2 + 2]‐Cycloadditions

open access: yesAngewandte Chemie International Edition, EarlyView.
In this study, we capitalize on the versatility offered by genetic code expansion to develop a proficient photoenzyme for [2 + 2]‐cycloadditions that is enantiocomplementary to our recently developed photoenzyme EnT1.3. By repositioning the genetically programmed benzophenone photosensitizer and subsequent directed evolution, we have developed an ...
Chuanjie Sun   +9 more
wiley   +1 more source

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