Results 171 to 180 of about 27,606 (220)

Bioinspired, Guanidinium, and Indole Modified Poly(glycidyl ether)s as Highly Efficient Vectors for Polyplex‐Mediated Gene Delivery

Macromolecular Rapid Communications, EarlyView.
Guanidinium‐ and indole‐functionalized poly(glycidyl ether)s were developed as non‐viral gene delivery vectors with tunable hydrophilic–hydrophobic balance. All polymers formed stable DNA polyplexes, while moderate indole content yielded the highest transfection efficiency at low N/P ratios.
Markus Kötzsche, Andreas Dzierza, Lennert Sölter, Jan Egger, Kjell Cornelis, Andreas Stihl, Felix H. Schacher, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Cobalt-catalyzed direct carbonylative 3-acylation of (N-H)Indoles with alkyl halides. [PDF]

Chem Sci
Xu C, Bao ZP, Shao S, Wu XF.
europepmc   +1 more source

Data‐Driven Engineering of Thermostable Collagen‐Mimetic Peptoid Triple Helices

Macromolecular Rapid Communications, EarlyView.
Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Alex Berlaga, Renyu Zheng, Zeqian Zhang, Junhee Lee, Diya Gandhi, Chun‐Long Chen, Andrew L. Ferguson   +6 more
wiley   +1 more source

Cationic Au(I) Complexes of Indoles. [PDF]

ACS Org Inorg Au
Milcendeau P, Ramdani M, van Elslande E, Guinchard X.   +3 more
europepmc   +1 more source

Therapeutic Potential of Fecal Microbiota Transplantation for Male Sexual Dysfunction: Evidence and Clinical Perspectives

Microbiota Medicine Research, EarlyView.
ABSTRACT Fecal microbiota transplantation (FMT), a microbiome‐based therapy, shows potential in treating male sexual dysfunction. Research into the influence of FMT on male sexual function has recently garnered increasing attention. This review aims to explore the impact of FMT on male sexual function and the underlying mechanisms, and to analyze the ...
Junyi Chen, Chenfeng Bu, Xia Li, Lei Wu, Xingxiang He   +4 more
wiley   +1 more source

Photo/electro-mediated radical cascade functionalization/cyclization reactions involving <i>N</i>-acryloyl 2-aryl indoles/benzimidazoles. [PDF]

RSC Adv
Doraghi F, Abbasi A, Zomorodiyan N, Kermaninia S, Dostkoh RH, Larijani B, Mahdavi M.   +6 more
europepmc   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Recent Advancements in Photocatalytic Synthesis of Five Membered Nitrogen Heterocycles and Their Derivatives. [PDF]

Molecules
Haider Z, Archana R, Ju H.
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Microbiome-Derived Indole-3-Lactic Acid Attenuates <i>Cutibacterium Acnes</i>-Induced Inflammation via the Aryl Hydrocarbon Receptor Pathway. [PDF]

Int J Mol Sci
Lee SG, Chau NH, Ham S, Baek Y, Nguyen NH, Kim SH, Lee YI.   +6 more
europepmc   +1 more source