Results 261 to 270 of about 200,870 (399)

A Precise Synthetic Toolbox: H-Bond-Assisted Quadruple Reactivity of <i>o</i>-Dimethylaminoaryloximes. [PDF]

open access: yesJ Org Chem
Tsybulin SV   +5 more
europepmc   +1 more source

Halogencarbene-free Ciamician-Dennstedt single-atom skeletal editing. [PDF]

open access: yesNat Commun
Liu S   +8 more
europepmc   +1 more source

Excited‐State Basicity Diverts the Site‐Selectivity of Aromatic Deuteration: Application to the Late‐Stage Labeling of Pharmaceuticals

open access: yesAngewandte Chemie International Edition, EarlyView.
We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao   +5 more
wiley   +1 more source

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