Results 71 to 80 of about 27,606 (220)
Angewandte Chemie, EarlyView.A NiH‐catalyzed α‐alkenylation via Markovnikov hydronickellation of alkynes enables convenient access to α‐chrial β‐methylene carbonyl frameworks that are prevalent in biorelevant molecules. High regio‐ and enantioselectivities have been achieved with excellent functional group tolerance and applicability toward complex structures. The β‐methylene unit
Hyeontaek Nam +3 more
wiley +2 more sources
Advanced Intelligent Systems, EarlyView.This study provides an introduction to Bayesian optimisation targeted for experimentalists. It explains core concepts, surrogate modelling, and acquisition strategies, and addresses common real‐world challenges such as noise, constraints, mixed variables, scalability, and automation.
Chuan He +2 more
wiley +1 more source
Angewandte Chemie, EarlyView.Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada +5 more
wiley +2 more sources
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
Copper(II)-Catalyzed Direct C3 Chalcogenylation of Indoles
Molecules3-Chalcogenylindoles serve as crucial building blocks in organic synthesis and pharmaceutical chemistry. Herein, we describe a simple and general synthesis of 3-chalcogenylindoles through the direct C–H chalcogenation of indoles using N-selenophthalimide
Liuyan Pan +5 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2015 The synthesis of N-arylated pyrroles and indoles is documented, as well as their functionalization by deprotonative metallation using the base in situ prepared from LiTMP and ZnCl2·TMEDA (1/3 equiv).
Mohamed Yacine Ameur Messaoud +12 more
doaj +1 more source
Aminofluorination of 2-alkynylanilines: a Au-catalyzed entry to fluorinated indoles
Beilstein Journal of Organic Chemistry, 2014 The scope and limitations of gold-catalyzed tandem cycloisomerization/fluorination reactions of unprotected 2-alkynylanilines to have access to 3,3-difluoro-2-aryl-3H-indoles and 3-fluoro-2-arylindoles are described.
Antonio Arcadi +3 more
doaj +1 more source
Allenylphosphine oxides as simple scaffolds for phosphinoylindoles and phosphinoylisocoumarins
Beilstein Journal of Organic Chemistry, 2014 A range of phosphinoylindoles was prepared in one-pot from functionalized propargyl alcohols and a suitable P(III) precursor via a base-mediated reaction. The reaction proceeds via the intermediacy of allenylphosphine oxides.
G. Gangadhararao +3 more
doaj +1 more source
Frontiers in Chemistry, 2018 Duckweed farming can be a sustainable practice for biofuel production, animal feed supplement, and wastewater treatment, although large scale production remains a challenge.
Sarah Gilbert +5 more
doaj +1 more source
Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models
Anais da Academia Brasileira de CiênciasThe N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed
BENEDITO P. SOUSA-NETO +7 more
doaj +1 more source