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The emerging role of the Hippo signaling pathway in interorgan crosstalk
The FEBS Journal, EarlyView.Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song +2 more
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Total synthesis of the indole alkaloid (±)-tacamine
Tetrahedron Letters, 1994Abstract The mixture of pentacyclic intermediates ( 4 ) was successfully converted into the pharmacologically interesting indole alkaloid (±)-tacamine ( 1 ). In a similar manner, the two unnatural isomers of 1 , (±)-14-epitacamine ( 9 ) and (±)-14-epi-16-epitacamine ( 10 ), were obtained from intermediate 7 .
Mauri Lounasmaa +2 more
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Total Synthesis of the Monoterpenoid Indole Alkaloid (±)‐Aspidophylline A
Angewandte Chemie, 2014AbstractAspidophylline A belongs to the akuammiline alkaloid family, the members of which possess intriguing cagelike structures and diverse biological activities. Herein we report a 15‐step synthesis of this alkaloid from conveniently available starting materials. The key elements of the synthesis include an intramolecular oxidative coupling to create
Mingxing, Teng, Weiwei, Zi, Dawei, Ma
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Total Synthesis of Indole Alkaloid Alsmaphorazine D
Angewandte Chemie International Edition, 2014AbstractA concise total synthesis of rac‐alsmaphorazine D has been described for the first time. The efficient synthetic strategy features four key transformations: 1) a catalytic intramolecular oxidative cyclization for the δ‐lactamindole backbone; 2) an oxidative cyclic aminal formation for the hexahydropyrrolo[2,3‐b]pyrrole framework; 3) a ...
Chenlong, Zhu +4 more
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Total Synthesis of Indole Alkaloid (±)-Subincanadine E
Organic Letters, 2014The first total synthesis of indole alkaloid (±)-subincanadine E has been accomplished. Ni(COD)2-mediated intramolecular Michael addition and zinc-mediated fragmentation reaction served as two key transformations.
Jingjing, Tian +5 more
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Total Syntheses of (−)‐Strictosidine and Related Indole Alkaloid Glycosides
Angewandte Chemie, 2020AbstractA collective synthesis of glycosylated monoterpenoid indole alkaloids is reported. A highly diastereoselective Pictet–Spengler reaction with α‐cyanotryptamine and secologanin tetraacetate as substrates, followed by a reductive decyanation reaction, was developed for the synthesis of (−)‐strictosidine, which is an important intermediate in ...
Jukiya Sakamoto +4 more
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Total synthesis of indole alkaloid pendolmycin
Tetrahedron, 1990Abstract The teleocidin class of an indole alkaloid, pendolmycin (1) was synthesized from 1-(4-methylphenylsulfonyl)pyrrole in thirteen steps by way of the indole derivative (16), the amino- diester compound (6), and the ethyl carboxylate (5).
Kazuaki Okabe +2 more
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Total synthesis of monoterpenoid indole alkaloid (–)-arbophyllidine
Organic Chemistry Frontiers, 2022The first asymmetric total synthesis of (–)-arbophyllidine, an unusual pentacyclic monoterpenoid indole alkaloid, has been achieved.
Hongbin Zhai +5 more
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Green oxidation of indoles and collective total syntheses of indole alkaloids
2023Indole alkaloids and their derivatives are among the largest families of natural products and bioactive molecules. Many of them exhibit significantly biological and physiological activities and are used as therapeutic agents for various diseases. The medicinal value has driven the indoles research including chemical synthesis, which plays an important ...
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Asymmetric Total Syntheses of Kopsia Indole Alkaloids
Angewandte Chemie International Edition, 2017AbstractThe asymmetric total syntheses of a group of structurally complex Kopsia alkaloids, (−)‐kopsine, (−)‐isokopsine, (+)‐methyl chanofruticosinate, (−)‐fruticosine, and (−)‐kopsanone, has been achieved. The key strategies for the construction of the molecular complexity in the targets included an asymmetric Tsuji–Trost rearrangement to set the ...
Lingying, Leng +7 more
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