Results 91 to 100 of about 174 (166)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

The shared benefits of fallen fruits: A novel mechanism stabilizing a nursery pollination mutualism between Sambucus and kateretid beetles

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how cooperative interactions remain stable matters for biodiversity because many plants rely on specialist insects that can also impose reproductive costs. We studied the interaction between Sambucus sieboldiana and seed‐consuming Heterhelus beetles through detailed field observations and pollination experiments.
Suzu Kawashima, Hidehito Okada, Sadatomo Hisamatsu, Kenji Suetsugu   +3 more
wiley   +1 more source

Arbuscular mycorrhizal fungi enhance plant performance in trace element‐contaminated soils with element‐specific accumulation patterns

PLANTS, PEOPLE, PLANET, EarlyView.
Soil contamination by toxic trace elements is a growing global challenge that threatens food safety, agricultural productivity, and ecosystem health. We combined results from many experiments worldwide to assess whether beneficial soil fungi can help plants cope with contaminated soils.
Zahraddeen Kabir Sani, Jean Legeay, Mohamed Hijri   +2 more
wiley   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Behavioural manipulation of the cabbage stem flea beetle (Psylliodes chrysocephala L): Prospects for push–pull strategies in oilseed rape

Pest Management Science, EarlyView.
Behavioural manipulation of Psylliodes chrysocephala provides promising opportunities for sustainable pest management in oilseed rape systems. This review synthesises evidence on glucosinolates and their volatile isothiocyanate derivatives as phagostimulants and attractants, alongside the repellent or antifeedant effects of non‐host plants, plant ...
Suleiman Mustapha, Patricia A Ortega‐Ramos, Jozsef Vuts, Tariq M Butt, E. Joel Loveridge, Daniel Rüde, Samantha M Cook   +6 more
wiley   +1 more source

Combined application of Bacillus velezensis JDB15 and Trichoderma harzianum JDL4 suppresses banana Fusarium wilt under controlled conditions

Pest Management Science, EarlyView.
The surfactin C secreted by JDB15 and the probable parasitism of JDL4 lead to the leakage of intracellular macromolecules and the degradation of hyphae, respectively. Combined application of the two strains effectively controls banana Fusarium wilt under controlled conditions.
Deng Chen, Minghao Ju, Hongyang Li, Junting Feng, Xueyong Zi, Xuqian Gong, Yida Che, Xiaoya Lei, Zihuan Geng, Hongsen Deng, Kang Zhao, Jianghui Xie, Xiao‐Lin Chen, Jun Peng   +13 more
wiley   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

Photocatalytically Active Mechanically Interlocked Carbon Nanotubes

Small, EarlyView.
Mechanically interlocked CNTs (MINTs) are studied as heterogeneous photocatalysts. Two different motifs are presented, which own enhanced activity versus homogeneous systems at very low loadings, high TON, excellent recyclability, varied scope and no leaching.
Paula Blanco‐Caamano, Fernando Aguilar‐Galindo, Andrei G. Borisov, Sergio Díaz‐Tendero, Matías Blanco, José Alemán   +5 more
wiley   +1 more source

Enhanced through‐bond energy transfer‐based bioorthogonal probe enables catalytic‐amplified and sensitive detection of microRNA‐21 for clinical lung cancer diagnosis

Smart Molecules, EarlyView.
Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Yikun Li, Fuping Han, Haiqiao Huang, Danhong Zhou, Saran Long, Wen Sun, Jianjun Du, Jiangli Fan, Jing Ning, Chong Peng, Xiaojun Peng   +10 more
wiley   +1 more source