Results 81 to 90 of about 90,075 (209)
An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as Reductant
, 2011 An Efficient Route to 2,3-Disubstituted Indoles via Reductive Alkylation Using H2 as ...
曹亮亮 +3 more
core
Advanced Science, EarlyView.Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman +11 more
wiley +1 more source
pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone
Angewandte Chemie, EarlyView.AchC is an ATP‐independent, pH‐responsive chaperone. AchC functions as a molecular switch, sensing pH changes and undergoing a two‐stage conformational transition: C‐terminal extension (colored in yellow) loosening at mild pH 4.0–5.5 and monomerization at strong acidic pH 3.0.
Soojeong Ham +4 more
wiley +2 more sources
Radical intermediates in the peroxidation of indoles
, 2001 2-Substituted and 1,2-disubstituted indoles react with m-chloroperbenzoic acid and hydrogen peroxide in the presence of acid or calcium chloride affording 2- and 3-(3-oxoindol-2-yl)indoles; whereas 2,3-disubstituted indoles, reacting with the same ...
P. ASTOLFI +10 more
core +1 more source
Photocatalytic Alkylation of Pyrroles and Indoles with α-Diazo Esters [PDF]
, 2019 This article describes direct photoalkylation of electron-rich aromatic compounds with diazo compoiunds. C-2 alkylated indoles and pyrroles are obtained with good yields even though the photocatalyst (Ru(bpy)3Cl2) loading is as low as 0.075 mol %.
Jakub, Durka +2 more
core +1 more source
Advanced Science, EarlyView.Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han +11 more
wiley +1 more source
Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis
Advanced Science, EarlyView.A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen +12 more
wiley +1 more source
Cobalt‐Catalyzed [2σ+2π] Cycloaddition via Site‐Selective Capture of Bicyclobutane Diradical
Angewandte Chemie, EarlyView.We report a Co(II)‐catalyzed strategy that combines thermal activation of bicyclo[1.1.0]butane (BCBs) with site‐selective radical capture to furnish head‐to‐head fused bicyclo[2.1.1]hexanes via [2σ+2π] cycloaddition with indoles. Detailed mechanistic studies (31P NMR, EPR, CV, and DFT) support the catalytic pathway, while phosphine‐oxide trapping and X‐
Tanmayee Nanda +8 more
wiley +2 more sources
Novel synthesis of 3,4-fused indoles
, 2001 The goal of this project was to synthesize 3,4-fused indoles having a variety of ring sizes and a variety of functional groups. This has been accomplished by the development of a novel palladium-catalyzed route to 3,4-fused indoles. The key steps are two
Hubbard, Jeremiah Wallace
core +1 more source
Advanced Science, EarlyView.A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang +11 more
wiley +1 more source