Results 81 to 90 of about 887 (215)

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Síntesis de heterociclos vía reacciones de transferencia electrónica: Nuevas estrategias de arilación intramolecular [PDF]

, 2018
La síntesis orgánica es un área central de investigación, ya que permite la construcción de moléculas de relevada importancia en distintos campos de aplicación, incluyendo la química medicinal.
Guerra, Walter Damián
core  

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Probing the Influence of Sulfur–Aromatic Interactions on the Electronic Structure of Gas‐Phase Peptides

Chemistry – A European Journal, EarlyView.
Just as fingerprints reveal identity, spectroscopic fingerprints reveal molecular secrets. In this article, we show parts of the unique fingerprint of the sulfur–aromatic interaction. By measuring how this force alters the electronic structure of gas‐phase peptides, we provide a fundamental understanding of interactions that give insights into the ...
Laura Pille, Carlos Ortiz‐Mahecha, Bart Oostenrijk, Juliette Leroux, Marion Girod, Konstantin Hirsch, Luke MacAleese, Robert Horst Meißner, Debora Scuderi, Isaak Unger, Vicente Zamudio‐Bayer, Sadia Bari, Lucas Schwob   +12 more
wiley   +1 more source

Nouvelles voies d'accès à des hétérocycles substitués : par hydrogénation d'indoles, réaction de Prins, d'aza-Prins et application à la synthèse des decytospolides A et B [PDF]

, 2013
The heterocyclic skeleton is present in many natural and synthetic products with biological activity. The development of methods to build these patterns is an important area of research and many synthetic routes have been and are still being studied ...
Clarisse, Damien
core   +2 more sources

Biocontrol in vitro e in vivo de aislados no defoliantes (ND) de Verticillium dahliae obtenidos de olivo (Olea europaea) en Catamarca y La Rioja con cepas nativas identificadas y caracterizadas de Trichoderma del noroeste de Argentina [PDF]

El olivo, en el noroeste de Argentina, representa una importante fuente de ingresos por la exportación de aceite y aceituna de mesa. Entre los patógenos que causan pérdidas importantes, en Catamarca y La Rioja, se destacan los aislados no defoliantes (ND)
Carrasco, Franca Denise
core   +1 more source

Insights into the Photocatalytic Arene Bromination Enabled by Cs2AgBiBr6 Microparticles

Chemistry – A European Journal, EarlyView.
A sustainable photocatalytic bromination of electron‐rich arenes is enabled by low‐toxicity Cs2AgBiBr6 double‐perovskite microparticles using HBr as an atom‐economical bromine source. Surface‐derived bromine radicals drive highly selective mono‐bromination under mild conditions.
Daniele Conelli, Chiara Lo Porto, Mokurala Krishnaiah, Kimmo Lahtonen, G. Krishnamurthy Grandhi, Nicola Margiotta, Paola Vivo, Gian Paolo Suranna, Roberto Grisorio   +8 more
wiley   +1 more source

Aislamiento y caracterización de azospirillum sp. inoculado en el cultivo de chile jalapeño (capsicum annuum l. híbrido “grande”) [PDF]

, 2013
"El objetivo del estudio fue aislar y caracterizar cepas rizosféricas de Azospirillum sp. para evaluar su potencial biofertilizante en plantas de chile jalapeño (Capsicum annuum L. Híbrido “Grande”). La investigación se realizó en dos etapas durante 2011
Nuncio Orta, Gloria Laura
core  

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

Chemistry – A European Journal, EarlyView.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +1 more source