Results 101 to 110 of about 90,075 (209)

Supporting Information of the manuscript " Iridium-Catalyzed Tandem Dehydrogenation/Hydroarylation Approach to Synthetically Versatile C2-Alkenyl N–H Indoles"

open access: yes
1. General Procedures S3 2. Optimization and additional control experiments S4 3. Procedures for the synthesis of reaction precursors S8 4. Ir-catalyzed tandem processes S12 - General procedure B: Tandem dehydrogenation/hydroarylation of N-carbamoyl ...
López García, Fernando José   +2 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Near Infrared Photoswitching by Direct Excitation—A Next Frontier

open access: yesAngewandte Chemie International Edition, EarlyView.
Molecular photoswitches finally enter the spectral realm of near‐infrared for their direct excitation. This minireview summarizes the current state‐of‐the‐art, the design principles for achieving such low‐energy light responsiveness, and the unique applications that are unlocked by it.
Diptiprava Sahoo   +2 more
wiley   +1 more source

Atroposelective Access to Bicyclic Peptides via an Amide Photocaging Strategy

open access: yesAngewandte Chemie International Edition, EarlyView.
Ansamers are an atypical class of atropisomers (Pansa/Mansa) and stereoselective synthesis of its two conformational isomers is challenging. We introduce a photocaged amide protection strategy: photolabile groups in monocycles reversibly modulate amide geometry, biasing macrolactamization to selectively give Pansa or Mansa.
Haijian Yang   +7 more
wiley   +1 more source

Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups

open access: yesAngewandte Chemie International Edition, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari   +10 more
wiley   +1 more source

Longitudinal Modulation of the Gut Microbiome and Growth Performance by Phytochemicals as Antibiotic Alternatives in Swine Production

open access: yesAnimal Research and One Health, EarlyView.
We conducted a longitudinal trial across nursery, growing, and finishing phases, showing that phytochemical supplementation as a potential antibiotic alternative reduced potential pathogens and promoted beneficial Lactobacillus amylovorus in the nursery phase, and enriched amino acid and carbohydrate metabolism pathways (prediction) during finishing ...
Ziyu Liu   +11 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

open access: yesAnimal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang   +6 more
wiley   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

open access: yesAnimal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar   +8 more
wiley   +1 more source

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

open access: yesAnimal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi   +15 more
wiley   +1 more source

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