Results 151 to 160 of about 90,075 (209)

HOST MATTER: Parasite infection drives chemical reconfiguration of decomposing host and shapes insect behavioural responses

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Host–parasite interactions shape ecosystems by driving species dynamics, yet their influence is typically considered in terms of host mortality rather than the chemical environments generated during infection and decomposition.
Andrea Chacon‐Hurtado, Lucie De Wever, Fanny Ruhland, Pierre Hotermans, Clément Martin, Raquel Campos‐Herrera, François J. Verheggen   +6 more
wiley   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Volatile Compounds in Feathers of the Scarlet Macaw (Ara macao) Reflect Sex and Pair‐Bond Status

Integrative Zoology, EarlyView.
Scarlet macaws exhibit sex‐ and pair‐related differences in plumage volatile composition, with males showing greater chemical richness. Partnered individuals differ in specific compound classes, whereas no clear association with immune function was detected. These results support a potential role for olfactory cues in sexual and social communication in
Elisa Espartosa, Isabel Barja, José Martin, María del Carmen Hernández   +3 more
wiley   +1 more source

Single‐Cell Profiling Links T‐Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children

Allergy, EarlyView.
Active EoE is associated with more and deeper epithelial eosinophil, mast cell, and T cell infiltration; inactive EoE resembles controls. During remission, PPI treatment leaves more tissue resident CD3+ T‐cells than TS. In active EoE, TH2 cells, IL‐10hi Tregs, and CD8+ cytotoxic T cells are enriched, while TH17 cells are relatively depleted.
Hannes Hoelz, Matthias Tobias Warkotsch, Simon Buehler, Tim Faro, Sabrina Wagner, Valeriia Andrieieva, Alisia Beckmann, Anja Jurk, Marie‐Luise Frank, Guido Piontek, Kolja Siebert, Sebastian Jarosch, Sibylle Koletzko, Helga Paula Török, Christoph Walz, Martina Rudelius, Katja Steiger, Dirk Busch, Tobias Schwerd   +18 more
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Antimicrobial resistance patterns in bacterial isolates from mice and rats in Australian laboratory rodent facilities between 2015 and 2024

Australian Veterinary Journal, EarlyView.
Antimicrobial resistance (AMR) is a critical global challenge threatening human and animal health, food security and economic stability. Despite advances in understanding AMR trends of bacteria from humans, domestic animals, wildlife and environmental sources, there is limited understanding regarding AMR profiles of bacteria isolated from laboratory ...
RS Wilcox, L Rasmussen, CC Hill, LYP Fung, EN Simmonds, JM Devlin, MS Marenda, CR Wilks   +7 more
wiley   +1 more source

Updates in acute graft‐versus‐host disease: From novel pathogenic mechanisms to emerging therapeutic targets

British Journal of Haematology, EarlyView.
The graphical abstract provides a view on selected aspects of the pathogenesis, risk stratification and treatment of acute GVHD. Summary Acute graft‐versus‐host disease (aGVHD) remains a major complication following allogeneic haematopoietic stem cell transplantation (allo‐HSCT), representing a leading cause of non‐relapse mortality (NRM) and ...
Hazim Khatib, Robert Zeiser
wiley   +1 more source

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

Dietary melatonin and its benefits on cardiovascular disease

British Journal of Pharmacology, EarlyView.
Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane, Carmelita Abrahams, Sandrine Lecour   +2 more
wiley   +1 more source

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Total synthesis of the indole alkaloid (±)-tacamine

Tetrahedron Letters, 1994
Abstract The mixture of pentacyclic intermediates ( 4 ) was successfully converted into the pharmacologically interesting indole alkaloid (±)-tacamine ( 1 ). In a similar manner, the two unnatural isomers of 1 , (±)-14-epitacamine ( 9 ) and (±)-14-epi-16-epitacamine ( 10 ), were obtained from intermediate 7 .
Mauri Lounasmaa, David Din Belle, Arto Tolvanen   +2 more
openaire   +1 more source