Results 171 to 180 of about 90,075 (209)
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First Total Synthesis of Trimeric Indole Alkaloid, Psychotrimine
Organic Letters, 2007The first total synthesis of (+/-)-psychotrimine, a novel trimeric indole alkaloid isolated from Psychotria rostrata, was achieved. In the total synthesis, the copper-mediated intramolecular and intermolecular aminations of halobenzenes, which respectively contributed to the construction of a pyrrolidinoindoline core and the installation of a third ...
Yohei, Matsuda +2 more
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Total Synthesis of Sarpagine‐Related Bioactive Indole Alkaloids
Chemistry – A European Journal, 2018AbstractExtension of the asymmetric Pictet–Spengler reaction to bulkier Nb‐alkylated tryptophan derivatives resulted in an improved stereospecific access to the key bicyclo[3.3.1]nonane core of bioactive C‐19 methyl substituted sarpagine/macroline/ajmaline indole alkaloids with excellent diastereoselectivity by internal asymmetric induction.
M. Toufiqur Rahman +3 more
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Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement
Chemistry – A European Journal, 2016AbstractA short formal total synthesis of the marine natural product diazonamide A is described. The route is based on indole oxidative rearrangement, and a number of options were investigated involving migration of tyrosine or oxazole fragments upon oxidation of open chain or macrocyclic precursors.
Nadège David +4 more
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Fischer Indolizations as a Strategic Platform for the Total Synthesis of Picrinine
The Journal of Organic Chemistry, 2015Picrinine, which is a member of the akuammiline family of alkaloids, was first isolated in 1965 from the leaves of Alstonia scholaris. The natural product possesses a daunting polycyclic skeleton that contains a furanoindoline, a bridged [3.3.1]azabicycle, two N,O-acetal linkages, and six stereogenic centers.
Joel M, Smith +3 more
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A Divergent Enantioselective Total Synthesis of Post‐Iboga Indole Alkaloids
Angewandte Chemie International Edition, 2020AbstractDivergent enantioselective total syntheses of five naturally occurring post‐iboga indole alkaloids, dippinine B and C, 10,11‐demethoxychippiine, 3‐O‐methyl‐10,11‐demethoxychippiine, and 3‐hydroxy‐3,4‐secocoronaridine, as well as the two analogues 11‐demethoxydippinine A and D, are presented for the first time.
Jie Zhou, Dong‐Xing Tan, Fu‐She Han
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Total synthesis of the indole alkaloids henrycinol A and B
Tetrahedron, 2014Abstract The total synthesis of new indole alkaloids henrycinol A and B were accomplished starting from l -tryptophan methyl ester. The key step is a stereochemically flexible Pictet–Spengler reaction governed by the presence or absence of an N-allyl group in the tryptophan precursor.
Kavirayani R. Prasad +2 more
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Construction of cyclohepta[b]indoles in the total synthesis of indole alkaloids
2017[no abstract]
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Recent progress in the total synthesis of indole alkaloids.
Current opinion in drug discovery & development, 2010This review describes the most recent synthetic routes directed toward the construction of structurally complex indole alkaloids, many syntheses of which contain the asymmetric Pictet-Spengler reaction as a key stereochemical step. A kinetic and conformational study of the epimerization of cis 1,2,3-trisubstituted tetrahydro-beta-carbolines into their ...
Chitra R, Edwankar +5 more
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Total synthesis of the indole alkaloids ngouniensine and epingouniensine
Tetrahedron Letters, 1987Abstract The first total synthesis of ngouniensine and epingouniensine, by cyclization of a suitable 1-(3-indolylethyl)piperidine-2-carboxylic acid followed by the elaboration of the exocyclic methylene group, is reported.
Joan Bosch +4 more
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Angewandte Chemie International Edition, 2013
A variety of common, medium, and large ring fused tricyclic indoles including the fargesine precursor (XIV) are prepared from o-iodoaniline substrates under optimized conditions A).
Dong, Shan, Yan, Gao, Yanxing, Jia
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A variety of common, medium, and large ring fused tricyclic indoles including the fargesine precursor (XIV) are prepared from o-iodoaniline substrates under optimized conditions A).
Dong, Shan, Yan, Gao, Yanxing, Jia
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