Results 171 to 180 of about 887 (215)
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First Total Synthesis of Trimeric Indole Alkaloid, Psychotrimine
Organic Letters, 2007The first total synthesis of (+/-)-psychotrimine, a novel trimeric indole alkaloid isolated from Psychotria rostrata, was achieved. In the total synthesis, the copper-mediated intramolecular and intermolecular aminations of halobenzenes, which respectively contributed to the construction of a pyrrolidinoindoline core and the installation of a third ...
Yohei, Matsuda +2 more
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Total Synthesis of Sarpagine‐Related Bioactive Indole Alkaloids
Chemistry – A European Journal, 2018AbstractExtension of the asymmetric Pictet–Spengler reaction to bulkier Nb‐alkylated tryptophan derivatives resulted in an improved stereospecific access to the key bicyclo[3.3.1]nonane core of bioactive C‐19 methyl substituted sarpagine/macroline/ajmaline indole alkaloids with excellent diastereoselectivity by internal asymmetric induction.
M. Toufiqur Rahman +3 more
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Nonbiomimetic total synthesis of indole alkaloids using alkyne-based strategies
Organic & Biomolecular Chemistry, 2021Significance of nonbiomimetic natural product synthesis and nonbiomimetic total syntheses of indole alkaloids based on the construction of core structures using alkyne reactions are summarized in this review.
Hiroaki Ohno, Shinsuke Inuki
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Green oxidation of indoles and collective total syntheses of indole alkaloids
2023Indole alkaloids and their derivatives are among the largest families of natural products and bioactive molecules. Many of them exhibit significantly biological and physiological activities and are used as therapeutic agents for various diseases. The medicinal value has driven the indoles research including chemical synthesis, which plays an important ...
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A Divergent Enantioselective Total Synthesis of Post‐Iboga Indole Alkaloids
Angewandte Chemie International Edition, 2020AbstractDivergent enantioselective total syntheses of five naturally occurring post‐iboga indole alkaloids, dippinine B and C, 10,11‐demethoxychippiine, 3‐O‐methyl‐10,11‐demethoxychippiine, and 3‐hydroxy‐3,4‐secocoronaridine, as well as the two analogues 11‐demethoxydippinine A and D, are presented for the first time.
Jie Zhou, Dong‐Xing Tan, Fu‐She Han
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Total Synthesis of the Monoterpenoid Indole Alkaloid (±)‐Aspidophylline A
Angewandte Chemie, 2014AbstractAspidophylline A belongs to the akuammiline alkaloid family, the members of which possess intriguing cagelike structures and diverse biological activities. Herein we report a 15‐step synthesis of this alkaloid from conveniently available starting materials. The key elements of the synthesis include an intramolecular oxidative coupling to create
Mingxing, Teng, Weiwei, Zi, Dawei, Ma
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Tremorgenic Indole Alkaloids. The Total Synthesis of (−)-Penitrem D
Journal of the American Chemical Society, 2003A convergent, stereocontrolled total synthesis of the architecturally complex tremorgenic indole alkaloid (-)-penitrem D (4) has been achieved. Highlights of the synthesis include an efficient, asymmetric synthesis of the western hemisphere; the stereocontrolled assembly of the I-ring; discovery of a novel autoxidation to introduce the C(22) tertiary ...
Amos B, Smith +8 more
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Enantioselective total synthesis of the indole alkaloid 16-episilicine
Chemical Communications, 2009The first total synthesis of (-)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.
Mercedes, Amat +4 more
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Angewandte Chemie International Edition, 2013
A variety of common, medium, and large ring fused tricyclic indoles including the fargesine precursor (XIV) are prepared from o-iodoaniline substrates under optimized conditions A).
Dong, Shan, Yan, Gao, Yanxing, Jia
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A variety of common, medium, and large ring fused tricyclic indoles including the fargesine precursor (XIV) are prepared from o-iodoaniline substrates under optimized conditions A).
Dong, Shan, Yan, Gao, Yanxing, Jia
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Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement
Chemistry – A European Journal, 2016AbstractA short formal total synthesis of the marine natural product diazonamide A is described. The route is based on indole oxidative rearrangement, and a number of options were investigated involving migration of tyrosine or oxazole fragments upon oxidation of open chain or macrocyclic precursors.
Nadège David +4 more
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