Results 181 to 190 of about 887 (215)
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Hexacyclic indole alkaloids. A highly convergent total synthesis of cuanzine
The Journal of Organic Chemistry, 1991A novel route to the hexacyclic indole alkaloid cuanzine 1 has been developed. Key synthetic steps include the cyclocondensation of the imine 8 with the dihydrofuran 10 followed by homogeneous-catalyzed hydrogenation, wherein to COOMe group at C(20) serves as a diastereocontrol element in establishing the C(15) stereogenicity.
G. PALMISANO +4 more
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Journal of the American Chemical Society, 2013
A unified strategy allowing enantioselective total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, and (-)-leuconolam from a common cyclohexenone derivative was reported. The Suzuki-Miyaura reaction was used to couple two simple fragments incorporating the key elements for total synthesis, and unprecedented ...
Zhengren, Xu, Qian, Wang, Jieping, Zhu
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A unified strategy allowing enantioselective total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, and (-)-leuconolam from a common cyclohexenone derivative was reported. The Suzuki-Miyaura reaction was used to couple two simple fragments incorporating the key elements for total synthesis, and unprecedented ...
Zhengren, Xu, Qian, Wang, Jieping, Zhu
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Construction of cyclohepta[b]indoles in the total synthesis of indole alkaloids
2017[no abstract]
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Synlett, 2011
This account describes the development of a Diels-Alder-based methodology towards highly functionalized dihydronaphthalenamines, and their conversion into indoles through a modified Plieninger procedure. Applications towards the total synthesis of indole-containing natural products will be presented.
Michael Kerr +2 more
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This account describes the development of a Diels-Alder-based methodology towards highly functionalized dihydronaphthalenamines, and their conversion into indoles through a modified Plieninger procedure. Applications towards the total synthesis of indole-containing natural products will be presented.
Michael Kerr +2 more
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Recent progress in the total synthesis of indole alkaloids.
Current opinion in drug discovery & development, 2010This review describes the most recent synthetic routes directed toward the construction of structurally complex indole alkaloids, many syntheses of which contain the asymmetric Pictet-Spengler reaction as a key stereochemical step. A kinetic and conformational study of the epimerization of cis 1,2,3-trisubstituted tetrahydro-beta-carbolines into their ...
Chitra R, Edwankar +5 more
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Indole‐Diterpene Synthetic Studies: Total Synthesis of (−)‐21‐Isopentenylpaxilline
Helvetica Chimica Acta, 2003AbstractAn efficient, stereocontrolled total synthesis of the complex indole‐diterpene alkaloid (−)‐21‐isopentenylpaxilline (1) has been achieved. Key elements of the synthesis include the stereocontrolled construction of the advanced eastern hemisphere (−)‐68, involving a highly efficient union of the eastern and western fragments (−)‐68 and 5 ...
Amos B. Smith, Haifeng Cui
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Total synthesis of the indole alkaloids ngouniensine and epingouniensine
Tetrahedron Letters, 1987Abstract The first total synthesis of ngouniensine and epingouniensine, by cyclization of a suitable 1-(3-indolylethyl)piperidine-2-carboxylic acid followed by the elaboration of the exocyclic methylene group, is reported.
Joan Bosch +4 more
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Total Synthesis of the Tremorgenic Indole Diterpene Paspalinine
Angewandte Chemie International Edition, 2012Masaru, Enomoto +2 more
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Total Synthesis of the Indole Alkaloid Vallesiachotamine
Angewandte Chemie International Edition in English, 1984Dietrich Spitzner, Ernest Wenkert
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