T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Total syntheses of pyrroloazocine indole alkaloids: challenges and reaction discovery
Organic Chemistry Frontiers, 2018 Total syntheses of pyrroloazocine indole alkaloids (lapidilectines, grandilodines, lundurines and tenuisines) are discussed in terms of existing retrosynthetic solutions and novel reaction discoveries.
Mariia S. Kirillova +2 more
openaire +3 more sources
Aislamiento, selección e identificación de actinomicetos, bacterias fotosintéticas no sulfurosas y bacterias ácido lácticas con potencial biofertilizante, a partir de suelos asociados al cultivo de plátano en la Costa Atlántica Colombiana [PDF]
, 2011 El cultivo de plátano, requiere fertilización continua y uso de agroquímicos, deteriorando el medio ambiente y aumentando costos en la producción. Una alternativa a esta problemática es el uso de microorganismos nativos, capaces de proveer los nutrientes
Otero Jiménez, Vanessa
core +1 more source
Caracterización de consorcios de bacterias rizosféricas tolerantes al Cr+6 aisladas de malezas y su influencia en la fitorremediación de suelo contaminado [PDF]
, 2021 La presente investigación se realizó con el objetivo de determinar las características de los consorcios de bacterias rizosféricas tolerantes al Cr+6 aisladas de malezas y su influencia en la fitorremediación de suelo contaminado. Las malezas previamente
Recoba Colchón, Felipe Ernesto +1 more
core
Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions
Advanced Science, EarlyView.This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang +4 more
wiley +1 more source
Metabolitos secundarios de líquenes de la zona nival de la Sierra Nevada de Mérida-Venezuela y su papel en la absorción de la radiación ultravioleta [PDF]
, 2008 Photochemical analyses of secondary compounds in lichens from the venezuelan andean snow zone were carried out in order to know the absorbance capacity of UV radiation at the UVA, UVB and UVC ranges and to determine its probable UV protective function ...
Balza-Quintero, Alirio +7 more
core +2 more sources
The Emerging Parkinson's Disease Oxylipin‐Ome
Advanced Science, EarlyView.ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley +1 more source
Rancheros y sociedades rancheras [PDF]
, 1994 International ...
Hoffmann, Odile (ed.) +3 more
core +1 more source
ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy
Advanced Science, EarlyView.A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou +9 more
wiley +1 more source
Advanced Science, EarlyView.Transition‐metal phthalocyanine (TMPc) molecules serve as model systems for probing the spin interactions. This review summarizes recent scanning tunnelling microscopy advances on the spin‐related phenomena in TMPc adsorbates, including Kondo effect, spin excitations, and Yu–Shiba–Rusinov states, emphasizing the mechanisms and control strategies, and ...
Fudi Zhou +6 more
wiley +1 more source