Results 1 to 10 of about 390,247 (379)

Epigenetic memory in induced pluripotent stem cells [PDF]

Nature, 2010
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues.
K. Kim, Akiko Doi, Bo Wen, Kelvin S. Ng, Robert Chunhua Zhao, Patrick Cahan, Jonghwan Kim, Martin J. Aryee, Hong Ji, Lauren I. R. Ehrlich, Akiko Yabuuchi, Ayumu Takeuchi, K. C. Cunniff, Hongguang Huo, Shannon McKinney‐Freeman, Olaia Naveiras, Taeyeong Yoon, Rafael A. Irizarry, Namyoung Jung, Jun Seita, Jacob H. Hanna, Peter Murakami, Rudolf Jaenisch, Ralph Weissleder, Stuart H. Orkin, Irving L. Weissman, Andrew P. Feinberg, George Q. Daley   +27 more
core   +11 more sources

Induced pluripotent stem cell–related approaches to generate dopaminergic neurons for Parkinson’s disease [PDF]

Neural Regeneration Research
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson’s disease, the second most common human neurodegenerative disease.
Ling-Xiao Yi, Hui Ren Woon, Genevieve Saw, Li Zeng, Eng King Tan, Zhi Dong Zhou   +5 more
doaj   +2 more sources

Induced Pluripotent Stem Cells and Human Disease [PDF]

Cell Stem Cell, 2008
Two recent studies report the generation of induced pluripotent stem cells from patients presenting with a total of eleven different diseases (Park et al., 2008; Dimos et al., 2008). Future differentiation studies using these lines may offer insight on specific disease pathophysiology and aid the design of protective drug therapies.
Alan Colman
openalex   +5 more sources

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]

Stem Cells International, 2016
A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Aoife Gowran, Marco Rasponi, Roberta Visone, Patrizia Nigro, Gianluca L. Perrucci, Stefano Righetti, Marco Zanobini, Giulio Pompilio   +7 more
doaj   +4 more sources

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway [PDF]

Nature, 2009
Hyenjong Hong, Kazutoshi Takahashi, Tomoko Ichisaka, Takashi Aoi, Osami Kanagawa, Masato Nakagawa, Keisuke Okita, Shinya Yamanaka   +7 more
openalex   +2 more sources

Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette [PDF]

Stem Cells, 2008
Cesar Sommer, Matthias Stadtfeld, George J. Murphy, Konrad Hochedlinger, Darrell N. Kotton, Gustavo Mostoslavsky   +5 more
openalex   +2 more sources

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

Frontiers in Immunology, 2021
Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties.
Joel Jihwan Hwang, Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju, Ji Hyeon Ju   +4 more
doaj   +1 more source

An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]

, 2017
Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan, Bowles, Kathryn R, Brennand, Kristen J, Goate, Alison M, Hartley, Brigham J, Karch, Celeste M, Lacin, Emre, Machlovi, Saima I, Phatnani, Hemali, Pimenova, Anna A, Slesinger, Paul A, TCW, Julia, Wang, Minghui, Zhang, Bin   +13 more
core   +10 more sources

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
We examined whether it is possible to directly detect citrullinated antigens in the serum of rheumatoid arthritis (RA) patients using a monoclonal antibody (mAb) designed to be specific for citrullinated peptides. In order to confirm the potential of the
Pureun Won, Pureun Won, Youngkyun Kim, Youngkyun Kim, Youngkyun Kim, Hyerin Jung, Hyerin Jung, Yeri Alice Rim, Yeri Alice Rim, Dong Hyun Sohn, Dong Hyun Sohn, Dong Hyun Sohn, William H. Robinson, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju   +17 more
doaj   +1 more source

Pluripotency of induced pluripotent stem cells [PDF]

Journal of Animal Science and Biotechnology, 2012
Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Shaorong Gao, Lan Kang
openaire   +4 more sources