Results 41 to 50 of about 406,426 (351)

Biomaterial-Free Three-Dimensional Bioprinting of Cardiac Tissue using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

Scientific Reports, 2017
We have developed a novel method to deliver stem cells using 3D bioprinted cardiac patches, free of biomaterials. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), fibroblasts (FB) and endothelial cells (EC) were aggregated to ...
C. Ong, T. Fukunishi, Huaitao Zhang, C. Huang, Andrew Nashed, A. Blazeski, D. Disilvestre, L. Vricella, J. Conte, L. Tung, G. Tomaselli, N. Hibino   +11 more
semanticscholar   +1 more source

Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons? [PDF]

, 2013
Heart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the ...
Liao, S, Tse, HF
core   +2 more sources

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

Nature Biomedical Engineering, 2017
An in vitro model of the human kidney glomerulus—the major site of blood filtration—could facilitate drug discovery and illuminate kidney-disease mechanisms.
Samira Musah, A. Mammoto, Thomas C. Ferrante, Sauveur S. F. Jeanty, Mariko Hirano-Kobayashi, T. Mammoto, K. Roberts, Seyoon Chung, R. Novák, Miles Ingram, Tohid Fatanat-Didar, Sandeep T. Koshy, J. Weaver, G. Church, D. Ingber   +14 more
semanticscholar   +1 more source

Efficacy of MUC1-targeted CAR-NK cells against human tongue squamous cell carcinoma

Frontiers in Immunology
IntroductionThe clinical efficacy of CAR-NK cells against CD19-expressing blood cancers has been demonstrated, and they have shown potential for treating solid tumors as well.
Xiaolan Lin, Tian Guan, Tian Guan, Yun Li, Yun Li, Yanchun Lin, Yanchun Lin, Guowei Huang, Yan Lin, Pingnan Sun, Congzhu Li, Jiang Gu, Haoyu Zeng, Haoyu Zeng, Haoyu Zeng, Haoyu Zeng, Changchun Ma, Changchun Ma, Changchun Ma, Changchun Ma   +19 more
doaj   +1 more source

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

Haematologica, 2012
Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells ...
Ladan Kobari, Frank Yates, Noufissa Oudrhiri, Alain Francina, Laurent Kiger, Christelle Mazurier, Shaghayegh Rouzbeh, Wassim El-Nemer, Nicolas Hebert, Marie-Catherine Giarratana, Sabine François, Alain Chapel, Hélène Lapillonne, Dominique Luton, Annelise Bennaceur-Griscelli, Luc Douay   +15 more
doaj   +1 more source

The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients

Pain, 2019
Supplemental Digital Content is Available in the Text. Human sodium channel NaV1.7 in induced pluripotent stem cell–derived sensory neurons sets the action potential threshold but does not support subthreshold depolarizations.
J. Meents, E. Bressan, Stephanie Sontag, A. Foerster, P. Hautvast, Corinna Rösseler, M. Hampl, H. Schüler, Roman Goetzke, Thi Bao Chi Le, I. Kleggetveit, Kim Le Cann, Clara M Kerth, Anthony M. Rush, M. Rogers, Z. Kohl, M. Schmelz, W. Wagner, E. Jørum, B. Namer, B. Winner, M. Zenke, A. Lampert   +22 more
semanticscholar   +1 more source

Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Regenerative Therapy, 2017
Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno, Keiko Hiemori, Kazunari Hirayasu, Nagako Sougawa, Masakazu Fukuda, Masaki Warashina, Makoto Amano, Taku Funakoshi, Yoshifusa Sadamura, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Tomoko Shofuda, Miho Sumida, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano, Yasuko Onuma, Yuzuru Ito, Makoto Asashima, Jun Hirabayashi   +20 more
doaj   +1 more source

Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity

SAGE Open Medicine, 2020
Objectives: To establish a straightforward single-cell passaging cultivation method that enables high-quality maintenance of human induced pluripotent stem cells without the appearance of karyotypic abnormalities or loss of pluripotency.
Estela Cruvinel, Isabella Ogusuku, Rosanna Cerioni, Sirlene Rodrigues, Jéssica Gonçalves, Maria Elisa Góes, Juliana Morais Alvim, Anderson Carlos Silva, Vanesca de Souza Lino, Enrique Boccardo, Ernesto Goulart, Alexandre Pereira, Rafael Dariolli, Marcos Valadares, Diogo Biagi   +14 more
doaj   +1 more source

Advances in human stem cell therapies: pre-clinical studies and the outlook for central nervous system regeneration

Neural Regeneration Research, 2021
Cell transplantation has come to the forefront of regenerative medicine alongside the discovery and application of stem cells in both research and clinical settings. There are several types of stem cells currently being used for pre-clinical regenerative
Lindsey H Forbes, Melissa R Andrews
doaj   +1 more source

Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]

, 2017
Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H., Clark, Alex J., Galino, Jorge, Kaller, Malte S., Rinaldi, Simon, Willison, Hugh J.   +5 more
core   +2 more sources