Results 141 to 150 of about 7,556,090 (298)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Inhibition of ERK and GSK3 signalling pathways promotes development and expression of pluripotent markers in bovine blastocysts [PDF]

, 2012
Embryo-derived pluripotent stem cells (ePSCs) naturally derive from different founder tissues, namely the early and late epiblast, that vary in their cellular characteristics. Recent evidence in mice suggests these sources of starting material correspond
Harris, Daina
core  

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer [PDF]

, 2012
In recent years, the cancer stem cell hypothesis has emerged as a compelling but controversial model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are ...
Dunning-Foreman, NL
core  

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) are a type of stem cell that are generated from adult somatic cells through genetic reprogramming and have the ability to differentiate into various types of cells in the body. These cells were introduced in 2006 by Shinya Yamanaka and his colleagues, and since then, they have been recognized as a powerful tool in
Mahmood S Choudhery, Ruhma Mahmood, Taqdees Arif   +2 more
openaire   +2 more sources

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Advancements in differentiation of induced pluripotent stem cells into specialized neuronal subtypes

Neural Regeneration Research
The ability to generate specialized human neurons from induced pluripotent stem cells has revolutionized neuroscience, regenerative medicine, and drug discovery. Since their discovery, induced pluripotent stem cells have emerged as an ethically favorable
Selena Setsu, Hideyuki Okano, Satoru Morimoto   +2 more
doaj   +1 more source

Magnetoelectric BaTiO3/CoFe2O4 Thin‐Film Meshes for Neuronal Differentiation

Advanced Science, EarlyView.
We engineer an epitaxial BaTiO3/CoFe2O4 magnetoelectric mesh that overcomes boundary‐induced mechanical clamping. Progressively reducing the mechanical constraint, from substrate‐clamped to PDMS‐transferred and ultimately freestanding, enhances magnetic‐to‐electric transduction and strengthens magnetoelectric coupling.
Mathieu Mirjolet, Hao Ye, Abderrahim Lahlahi Attalhaoui, Donghoon Kim, Vitaly Pustovalov, Elric Zhang, Marc Tudela‐Pi, Bastian Gebauer, Juan Bautista Carda Castelló, Anton Guimerà‐Brunet, Josep Puigmartí‐Luis, Xiang‐Zhong Chen, Minsoo Kim, Salvador Pané   +13 more
wiley   +1 more source