Results 121 to 130 of about 121,384 (261)

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Genetics of growth rate in induced pluripotent stem cells. [PDF]

Stem Cell Reports
Lee BN, Taylor HJ, Cipriani F, Narisu N, Robertson CC, Swift AJ, Sinha N, Yan T, Bonnycastle LL, Dale N, Butt A, Parsaud H, Semrau S, NYSCF Global Stem Cell Array Team, GENESiPS Consortium, iPSCORE Consortium, Knowles JW, Carcamo-Orive I, D'Antonio-Chronowska A, Frazer KA, Biesecker LG, Noggle S, Erdos MR, Paull D, Collins FS, Taylor DL.   +25 more
europepmc   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Protocol for culture and maintenance of canine induced pluripotent stem cells. [PDF]

STAR Protoc
Shishida K, Tsukamoto M, Nishimura T, Hatoya S.   +3 more
europepmc   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Generation of therapeutic T cells from human induced pluripotent stem cells. [PDF]

Inflamm Regen
Wang B, Kaneko S.
europepmc   +1 more source

Cardiovascular Organoids With Adjustable Endothelial Composition via SOX17‐Engineered hPSCs

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Organoids are considered a novel modeling platform for studying human biology and advancing health research. With the ability to demonstrate complex 3D structure and multicellular interactions, organoids have advanced studies in all major organs as a reliable model.
Po‐Yu Liang, Gyuhyung Jin, Nathan R. Petrucci, Xiaojun Lance Lian, Xiaoping Bao   +4 more
wiley   +1 more source

Induced pluripotent stem cells as platforms for engineering NK cell immunotherapies. [PDF]

Front Cell Dev Biol
Jezierski A, Huang J, Desbiens L, Benabdallah B, McComb S, Beausejour C.   +5 more
europepmc   +1 more source