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Correction: Generation of Human Melanocytes from Induced Pluripotent Stem Cells. [PDF]

PLoS One
Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y.   +10 more
europepmc   +1 more source

Immunogenicity of induced pluripotent stem cells [PDF]

Nature, 2011
Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined factors, hold great promise for regenerative medicine as the renewable source of autologous cells. Whereas it has been generally assumed that these autologous cells should be immune-tolerated by the recipient from whom the iPSCs are derived, their immunogenicity has ...
Yang Xu, Zhili Rong, Tongbiao Zhao
exaly   +6 more sources

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Induced pluripotent stem cells

Russian Journal of Genetics, 2009
Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC).
A I, Shevchenko, S P, Medvedev, N A, Mazurok, S M, Zakiian   +3 more
openaire   +2 more sources

Livestock Induced Pluripotent Stem Cells

Reproduction in Domestic Animals, 2012
ContentsChimeric animals generated from livestock‐induced pluripotent stem cells (iPSCs) have opened the door of opportunity to genetically manipulate species for the production of biomedical models, improving traits of agricultural importance and potentially providing a system to test novel iPSC therapies.
Y, Lu, J L, Mumaw, F D, West, S L, Stice
openaire   +2 more sources

Routes to induced pluripotent stem cells

Current Opinion in Genetics & Development, 2014
The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of hundreds of genes, making unique ...
Tyson Ruetz, Keisuke Kaji
openaire   +2 more sources

Induced Pluripotent Stem Cells

2022
A limiting factor for the identification of disease mechanisms and development of new therapies has been the access to a model system/s that can faithfully recapitulate key features of the disease and more precise clinical translations of new treatments.
Ambrin Fatima, Uzma Abdullah, Zafar Ali
openaire   +2 more sources

Mouse-Induced Pluripotent Stem Cells

2012
Pluripotent stem cells belong to a unique population of cells, which can self-renew indefinitely and have the potential to give rise to all cell types in an organism. Generally, pluripotent stem cells include embryonic stem cells (ESCs), embryonic germ cells (EGCs), and embryonal carcinoma cells (ECCs) (Boiani and Scholer 2005).
Hui, Zhang, Ying, Jin
openaire   +2 more sources

Generation of Induced Pluripotent Stem Cells

2014
Induced pluripotent stem cells (iPSCs) are generated from somatic cells that have been reprogrammed by the ectopic expression of defined embryonic transcription factors. This technology has provided investigators with a powerful tool for modeling disease and developing treatments for human disorders.
openaire   +3 more sources

Stem Cells, Induced Pluripotent

2021
Induced pluripotent stem cells (iPSCs) refer to a type of stem cell directly generated using reprogramming techniques from multipotent adult stem cells. Therefore iPSCs gained a lower level of differentiation and could present themselves as pluripotent.
Henk ten Have, Maria do Céu Patrão Neves   +1 more
openaire   +1 more source

Generation of Induced Pluripotent Stem Cells in Rabbits

2014
We describe a procedure for generating induced pluripotent stem cell lines in rabbits, using retroviral vectors expressing Oct4, Sox2, Klf4, and c-Myc of human origin to reprogram rabbit fibroblasts prepared from an ear skin biopsy. We also provide detailed procedures for characterizing the resulting iPSC lines, including the analysis of pluripotency ...
Afanassieff, Marielle, Tapponnier, Yann, Savatier, Pierre   +2 more
openaire   +4 more sources