Results 201 to 210 of about 12,028,372 (332)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Editorial: The Plant Holobiont Volume II: Impacts of the Rhizosphere on Plant Health

Frontiers in Plant Science, 2021
Nadia Lombardi, Nadia Lombardi, Sheridan Lois Woo, Sheridan Lois Woo, Sheridan Lois Woo, Sheridan Lois Woo, Francesco Vinale, Francesco Vinale, Francesco Vinale, David Turrà, David Turrà, Roberta Marra, Roberta Marra   +12 more
doaj   +1 more source

Microbe-induced resistance involves priming of direct or indirect defenses according to the stage of herbivory. [PDF]

New Phytol
Rivero J, Fernández I, Colina FJ, Touw AJ, Weinhold A, Rodríguez-Blanco PM, Kester K, Pozo MJ, van Dam NM, Martínez-Medina A.   +9 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Microbial-mediated induced resistance: interactive effects for improving crop health. [PDF]

Front Microbiol
Charpe AM, Aglave B, Ghosh DK.
europepmc   +1 more source

Induced resistance during the interaction pathogen x plant and the use of resistance inducers

, 2016
M. Oliveira, C. Varanda, M. Felix
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Arabidopsis phospholipid modifications mediate cellulase-induced resistance to a fungal peptide antibiotic by imposing cell polarity. [PDF]

New Phytol
Panthapulakkal Narayanan S, Dotson BR, Noack L, Holla S, Ren S, Dörmann P, Widell S, Persson S, Lager I, Rasmusson AG.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Melatonin-induced resistance response activation against Fusarium oxysporum f. sp. lycopersici development in tomatoes. [PDF]

Sci Rep
Arshad H, Anwar W, Khurshid M, Javed S, Akhter A, Avila-Quezada GD, Abd-Allah EF, Hashem A.   +7 more
europepmc   +1 more source