Results 211 to 220 of about 1,397,977 (265)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition. [PDF]

open access: yesApoptosis
Pervushin NV   +8 more
europepmc   +1 more source

Ecological costs of induced resistance [PDF]

open access: possibleCurrent Opinion in Plant Biology, 2002
There has been rapid progress in detecting the genetic or allocation costs of induced resistance. In addition to these 'internal' costs, ecological costs may result from external mechanisms, that is, from the detrimental effects of resistance on the plant's interactions with its environment. All evolutionarily relevant costs affect a plant's ability to
Martin Heil
exaly   +4 more sources
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Induced Resistance to Streptomycin

The Journal of Immunology, 1947
Summary Some chromogenic bacteria and a group of salmonella strains were “trained” to high streptomycin resistance in vitro. A few equally resistant strains were recovered from streptomycin treated patients. Acquired resistance is accompanied by marked alteration of metabolic activities of the bacteria.
E, SELIGMANN, M, WASSERMANN
openaire   +2 more sources

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