Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Hepatitis B Virus-Induced Resistance to Sorafenib and Lenvatinib in Hepatocellular Carcinoma Cells: Implications for Cell Viability and Signaling Pathways. [PDF]
Esmael N, Lubin I, Tur-Kaspa R, Zemel R.
europepmc +1 more source
BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition. [PDF]
Pervushin NV +8 more
europepmc +1 more source
Comparative transcriptome analysis reveals the importance of phenylpropanoid biosynthesis for the induced resistance of 84K poplar to anthracnose. [PDF]
Xing F +5 more
europepmc +1 more source
Modulated critical currents of spin-transfer torque-induced resistance changes in NiCu/Cu multilayered nanowires. [PDF]
Fu M +5 more
europepmc +1 more source
Time-series transcriptomics reveals distinctive mRNA expression dynamics associated with gene ontology specificity and protein expression in skeletal muscle after electrical stimulation-induced resistance exercise. [PDF]
Kusano T +8 more
europepmc +1 more source
Ecological costs of induced resistance [PDF]
There has been rapid progress in detecting the genetic or allocation costs of induced resistance. In addition to these 'internal' costs, ecological costs may result from external mechanisms, that is, from the detrimental effects of resistance on the plant's interactions with its environment. All evolutionarily relevant costs affect a plant's ability to
Martin Heil
exaly +4 more sources
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Induced Resistance to Streptomycin
The Journal of Immunology, 1947Summary Some chromogenic bacteria and a group of salmonella strains were “trained” to high streptomycin resistance in vitro. A few equally resistant strains were recovered from streptomycin treated patients. Acquired resistance is accompanied by marked alteration of metabolic activities of the bacteria.
E, SELIGMANN, M, WASSERMANN
openaire +2 more sources

