Results 221 to 230 of about 12,028,372 (332)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Bringing Fundamental Insights of Induced Resistance to Agricultural Management of Herbivore Pests. [PDF]

open access: yesJ Chem Ecol, 2023
Poelman EH   +10 more
europepmc   +1 more source

When Do Antibiotics Induce “Resistance”? [PDF]

open access: yesInfectious Diseases in Obstetrics and Gynecology, 1996
openaire   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

Corrigendum: QTL for induced resistance against leaf rust in barley. [PDF]

open access: yesFront Plant Sci
Matros A, Schikora A, Ordon F, Wehner G.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma. [PDF]

open access: yesSci Rep
Santofimia-Castaño P   +8 more
europepmc   +1 more source

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