Results 241 to 250 of about 7,682,818 (299)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Various anthracyclines exhibit differential cytotoxic effects related to CBR1-induced resistance in lung cancer cells. [PDF]

Med Oncol
Piska K, Koczurkiewicz-Adamczyk P, Kochanowski P, Bobis-Wozowicz S, Władyka B, Pękala E.   +5 more
europepmc   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Modeling critical dosing strategies for stromal-induced resistance to cancer therapy. [PDF]

NPJ Syst Biol Appl
Kraut AK, Garvey CM, Strelez C, Mumenthaler SM, Foo J.   +4 more
europepmc   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Induced Resistance against Pseudomonas syringae pv. lachrymans in Cucumber by Spraying Cell-Free Microalgae Supernatant. [PDF]

Plant Pathol J
Lee SM, Son JS, Lee B, Chang YK, Shim CK, Ryu CM.   +5 more
europepmc   +1 more source

Induced resistance to herbivory and the intelligent plant. [PDF]

Plant Signal Behav
Kessler A, Mueller MB.
europepmc   +1 more source

Fitness costs associated with laboratory induced resistance to chlorpyrifos in Spodoptera litura. [PDF]

Sci Rep
Devi M, Sarkhandia S, Mahajan A, Saini HS, Kaur S.   +4 more
europepmc   +1 more source

Genomic characteristics of PD-L1-Induced resistance to EGFR-TKIs in lung adenocarcinoma. [PDF]

Future Oncol
Yi G, Cai F, Liu L, Liao R, Jiang X, Yang Z, Zhang X.   +6 more
europepmc   +1 more source