Results 241 to 250 of about 12,028,372 (332)

Revisiting Treatment Strategies: Addressing Epithelial-to-Mesenchymal Transition-Induced Resistance in Hepatocellular Carcinoma. [PDF]

BME Front
Naserkhaki R, Shokouhian B, Tahamtani Y, Khosravi A, Iravani S, Zarrabi A, Vosough M.   +6 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Multifactor transcriptional profiling of potato during 2,4-D-induced resistance to common scab disease. [PDF]

Front Plant Sci
Fabian ML, Nguyen HP, Stommel JR, Clarke CR.   +3 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Editorial: Microbial-mediated induced resistance: interactive effects for improving crop health. [PDF]

Front Microbiol
Mitra D, Rani A, Janeeshma E, Khoshru B.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Understanding therapeutic tolerance through a mathematical model of drug-induced resistance. [PDF]

NPJ Syst Biol Appl
Gevertz JL, Greene JM, Prosperi S, Comandante-Lou N, Sontag ED.   +4 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma. [PDF]

Blood Adv
Pignataro C, Zoppoli P, Cappelli LV, Yoffe L, Moretti M, Izzo M, Mallia S, Kayembe C, Taylor A, Petrillo G, Affinito A, Quintavalle C, De Luca G, Mascolo M, Verde S, Fraticelli A, Ciarrocchi A, Salerno P, De Smaele E, Campese AF, Fragliasso V, Foà R, Merla G, Inghirami G, Condorelli G, Fiore D.   +25 more
europepmc   +1 more source

Controlling crop diseases using induced resistance: challenges for the future.

Journal of Experimental Botany, 2013
D. Walters, Jaan Ratsep, N. Havis
semanticscholar   +1 more source