Results 21 to 30 of about 86,483 (258)

The six-gene expression signature in whole sampled sputum provides clinically feasible inflammatory phenotyping of asthma

ERJ Open Research, 2020
Processing of induced sputum is time consuming and requires trained personnel, and consequently the use of induced sputum is limited to few sites globally.
Laurits Frøssing, Ditte Kjærsgaard Klein, Vibeke Backer, Katherine Joanne Baines, Celeste Porsbjerg   +4 more
doaj   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Gibson, Anthony, Holz, Olaf, Janicki, Stanislawa, Jörres, Rudolf A., Kanniess, Frank, Magnussen, Helgo, Richter, Kai, Simpson, Kathy J., Tal-Singer, Ruth, Vessey, Rupert S. J.   +9 more
core   +1 more source

The role of induced sputum in the diagnosis of pulmonary tuberculosis

Lung India, 2013
Background: Microbiological confirmation of pulmonary tuberculosis (TB) is of paramount importance in the era of immunocompromised host and emergence of multi-drug resistance.
Saurabh Biswas, Anirban Das, Arijit Sinha, Sibes K Das, Tapan Das Bairagya   +4 more
doaj   +1 more source

Novel Method to Process Cystic Fibrosis Sputum for Determination of Oxidative State [PDF]

, 2010
Background: Induced sputum is the most commonly used method to analyze airway inflammation in cystic fibrosis (CF) patients ex vivo. Due to the complex matrix of the sample material, precise and reliable analysis of sputum constituents depends critically
Feilcke, M., Griese, M., Hartl, D., Hector, A., Jonas, F., Kappler, M.   +5 more
core   +1 more source

Glutathione s-transferase omega in the lung and sputum supernatants of COPD patients [PDF]

, 2015
BACKGROUND: The major contribution to oxidant related lung damage in COPD is from the oxidant/antioxidant imbalance and possibly impaired antioxidant defence. Glutathione (GSH) is one of the most important antioxidants in human lung and lung secretions,
Board, Philip, Harju, Terttu H, Kinnula, Vuokko L, Peltoniemi, Mirva J, Ruddock, Lloyd W, Rytila, Paula H, Salmenkivi, Kaisa M, Soini, Ylermi   +7 more
core   +1 more source

Microscopic Analysis and Quality Assessment of Induced Sputum From Children With Pneumonia in the PERCH Study. [PDF]

, 2017
BACKGROUND.: It is standard practice for laboratories to assess the cellular quality of expectorated sputum specimens to check that they originated from the lower respiratory tract. The presence of low numbers of squamous epithelial cells (SECs) and high
Ahmed, Dilruba, Awori, Juliet O, Baggett, Henry C, Brooks, W Abdullah, Deloria Knoll, Maria, DeLuca, Andrea N, Driscoll, Amanda J, Ebruke, Bernard E, Feikin, Daniel R, Hammitt, Laura L, Higdon, Melissa M, Hossain, Lokman, Howie, Stephen RC, Jorakate, Possawat, Karron, Ruth A, Kazungu, Sidi, Kotloff, Karen L, Kwenda, Geoffrey, Levine, Orin S, Madhi, Shabir A, Makprasert, Sirirat, Moore, David P, Morpeth, Susan C, Mudau, Azwifarwi, Murdoch, David R, Mwaba, John, O'Brien, Katherine L, Panchalingam, Sandra, Park, Daniel E, PERCH Study Group, Prosperi, Christine, Salaudeen, Rasheed, Scott, J Anthony G, Thea, Donald M, Toure, Aliou, Watson, Nora L, Zeger, Scott L   +36 more
core   +1 more source

Antagonism of cytokine-induced eosinophil accumulation in asthma [PDF]

, 2012
Peer reviewedPublisher ...
Walsh, Garry M.
core   +2 more sources

On the analysis of tuberculosis studies with intermittent missing sputum data [PDF]

, 2015
In randomized studies evaluating treatments for tuberculosis (TB), individuals are scheduled to be routinely evaluated for the presence of TB using sputum cultures. One important endpoint in such studies is the time of culture conversion, the first visit
Abraham, Maria, Chaisson, Richard, Geiter, Lawrence, McDermott, Aidan, Rotnitzky, Andrea Gloria, Scharfstein, Daniel   +5 more
core   +2 more sources

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Concentration of CCL11, CXCL8 and TNF-alpha in sputum and plasma of patients undergoing asthma or chronic obstructive pulmonary disease exacerbation

Brazilian Journal of Medical and Biological Research, 2005
Asthma and chronic obstructive pulmonary disease (COPD) are common respiratory illnesses characterized by chronic inflammation of the airways. The characterization of induced or spontaneously produced sputum is a useful technique to assess airway ...
M.B. Daldegan, M.M. Teixeira, A. Talvani
doaj   +1 more source