Results 61 to 70 of about 86,483 (258)

Pathophysiological Mechanisms of Asthma

Frontiers in Pediatrics, 2019
The recent Lancet commission has highlighted that “asthma” should be used to describe a clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough.
Andrew Bush
doaj   +1 more source

Anthropometric indices of Gambian children after one or three annual rounds of mass drug administration with azithromycin for trachoma control. [PDF]

, 2014
BACKGROUND: Mass drug administration (MDA) with azithromycin, carried out for the control of blinding trachoma, has been linked to reduced mortality in children.
A Amza, A Amza, A Sommer, A Weisz, AE Roth, AJ Weisz, Ansumana Sillah, C Nokes, C Panter-Brick, CG Victora, CJ Whitty, CL Coles, CL Coles, D Stare, David C W Mabey, EJ Giamarellos-Bourboulis, EK Gough, EM Harding-Esch, EM Harding-Esch, Emma M Harding-Esch, EV Basilion, I Udan, JD Keenan, JH Humphrey, John Hart, KL Kotloff, KN Ryan, L Leonor Rodríguez, LS Stephenson, Martin J Holland, MG Rowland, MG Rowland, MP Eccles, P Aaby, PG Lunn, R Goto, RL Guerrant, Robin L Bailey, S Haug, Sarah E Burr, T Edwards, Tansy Edwards, TC Porco, WHO, WHO, WHO, WHO   +46 more
core   +2 more sources

Disease Remission: A Scoping Review With Thematic Analysis of the Scientific Literature With Implications for Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Remission, a term used to describe a goal of treatment for some chronic diseases, has recently been proposed for chronic rhinosinusitis (CRS). However, it is unclear what remission means for CRS and why it should serve as a goal in the present‐day treatment of CRS.
Nikhil Parail, Lynn Warner, Stacey T. Gray, Claire Hopkins, Peter H. Hwang, Sarah K. Wise, Katie M. Phillips, Ahmad R. Sedaghat   +7 more
wiley   +1 more source

Determination of sputum eosinophil count and serum absolute eosinophil count in patients with bronchial asthma and its correlation with disease severity and response to treatment

Journal of Family Medicine and Primary Care, 2023
Background: Sputum eosinophils can be used to assess severity of disease and response to treatment in bronchial asthma. Eosinophilic inflammation in the airways can also be marked by blood eosinophilia.
Princia Banu Mangattu Parambil, Amrut K. Mohapatra, Debasis Behera, Saswat Subhankar, Suman K. Jagaty, Pratima Singh   +5 more
doaj   +1 more source

抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化 [PDF]

, 1992
Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood.
Kimura, Ikuro, Tanizaki, Yoshiro
core   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Environmental Arsenic Exposure and Microbiota in Induced Sputum [PDF]

International Journal of Environmental Research and Public Health, 2014
Arsenic exposure from drinking water is associated with adverse respiratory outcomes, but it is unknown whether arsenic affects pulmonary microbiota. This exploratory study assessed the effect of exposure to arsenic in drinking water on bacterial diversity in the respiratory tract of non-smokers.
White, Allison, Watts, George, Lu, Zhenqiang, Meza-Montenegro, Maria, Lutz, Eric, Harber, Philip, Burgess, Jefferey   +6 more
openaire   +2 more sources

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Nebulized heparin in burn patients with inhalation trauma : safety and feasibility [PDF]

, 2020
Background: Pulmonary hypercoagulopathy is intrinsic to inhalation trauma. Nebulized heparin could theoretically be beneficial in patients with inhalation injury, but current data are conflicting.
Binnekade, Jan M., Cleffken, Berry, Colpaert, Kirsten, Dixon, Barry, Glas, Gerie J., Hollmann, Markus W., Horn, Janneke, Juffermans, Nicole P., Knape, Paul, Levi, Marcel M., Loef, Bert G., Mackie, David P., Malbrain, Manu, Muller, Jan, Preckel, Benedikt, Reidinga, Auke C., Schultz, Marcus J., van der Sluijs, K.F.   +17 more
core   +2 more sources

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source